Multicenter Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD)

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    Recruiting
  • participants needed
    2400
  • sponsor
    Weidong Ren
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Updated on 16 February 2024
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body mass index
heart disease
electrocardiogram
respiratory system

Summary

To establish the range of TMADmidTMADmidpt% by using tissue motion tracking of mitral annular displacement (TMAD), and to explore the influencing factors.

Description

With the gradual aging of Chinese population and continuous development of economy and society, the incidence of cardiovascular disease and the number of patients have increased rapidly. The National Heart Center has reported that the number of patients with clinically diagnosed cardiovascular disease in China has reached 290 million in 2016 (240 million in 2014). Cardiovascular disease is the most common cause of death in humans. Left ventricular systolic function plays an important role in the treatment and prognosis of patients with myocardial diseases. Early sensitive detection of left ventricular systolic function, timely treatment and early evaluation of the therapeutic effect can greatly reduce the death of patients with myocardial diseases rate.

At present, the left ventricular ejection fraction (LVEF), measured by the two-plane Simpson method in clinical, is one of the methods to evaluating left ventricular systolic function. It is especially suitable for patients with geometric deformation of the left ventricle, but some early heart failure patients' LVEF is still in the normal range, whose systolic function has been reduced, but. In recent years, 2D longitudinal strain is one of the indicators for evaluating left ventricular systolic function. The researchers believe that 70% of cardiac function is obtained by longitudinal movement of myocardium , which can be used as a good indicator for identifying myocardial diseases. However, both the two-plane Simpson method and the 2D longitudinal strain require good sound transmission conditions and good image quality. You can clearly see the endocardium and epicardium. Not all of patients in the clinic can get better image.

Basic and clinical studies and clinical statistics show that tissue motion tracking of mitral annular displacement (TMAD) is not affected by image quality and can effectively evaluate left ventricular systolic function. It can measure the mitral valve annulus displacement by marking the mitral valve annulus point and the reference point, which can quickly and accurately evaluate the left ventricular longitudinal contraction function.

Details
Condition Left Ventricular Systolic Dysfunction, Healthy Volunteers
Age 18years - 79years
Treatment Echocardiography
Clinical Study IdentifierNCT04399447
SponsorWeidong Ren
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Han nationality
Ages 18-79
Normal body mass index (18-25kg / m2)
Normal blood pressure (139-90 / 89-60mmHg)
No history of cardiovascular and respiratory diseases
No abnormality was found in physical examination of cardiovascular and respiratory system
Blood glucose, lipid profile and electrocardiogram were normal
Echocardiography showed no structural heart disease and normal heart function
No history of medications affecting cardiovascular system

Exclusion Criteria

Clinically significant or moderate heart valve regurgitation
Respiratory diseases: acute or chronic respiratory diseases
Endocrine diseases: thyroid disease, diabetes, hyperaldosteronism, pheochromocytoma, and abnormal adrenal function
Anemia
Pregnant or lactating women
Abnormal liver function (glutamyl aminotransferase exceeds 2.0 times the upper limit of normal value), abnormal renal function (creatinine exceeds the normal value), increased blood lipids (triglycerides, total cholesterol, low density and high density lipoprotein, any of which is higher than Normal value)
Connective tissue disease
Tumor
Aortic and peripheral vascular diseases: aortic dilatation, aortic dissection, aortic constriction, multiple arteritis, and atherosclerosis
Drink more than 50ml of white wine daily; more than 100ml of red wine; more than 300ml of beer
Professional athletes
The poor quality of the ultrasound image cannot satisfy the parameter measurement and analysis
Clear my responses
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