Found 19 clinical trials
Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS) (phaethuSA)
Primary Objective: To evaluate the therapeutic efficacy of one dose level of SAR441344 versus placebo over 12 weeks in adult patients with primary Sjögren's syndrome (pSjS), assessed by the change of the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) Secondary Objectives: To evaluate the therapeutic efficacy …
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- 17 Nov, 2021
- 28 locations
A Study to Evaluate the Pharmacokinetics Safety and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants
Secondary objectives include evaluating the effect of mitapivat on electrocardiogram (ECG) parameters, including concentration-QT interval corrected for heart rate (C-QTc) analysis under fasted conditions. The study will include a 28-day screening period, four 7-day treatment periods.
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- 16 Feb, 2024
- 1 location
Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel
They will have a pregnancy test if needed. They will have an electrocardiogram to check their heart. They will have imaging scans to measure their tumors. Participants will repeat the screening tests during the study.
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- 16 Feb, 2024
- 1 location
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag
Blood and urine tests Bone marrow biopsy: A thin needle will remove a marrow sample from the participant s hip bone. Electrocardiogram Participants will take eltrombopag pills once daily for 24 weeks. They will have blood taken every 2 weeks. Participants will have visits 6 months.
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- 16 Feb, 2024
- 1 location
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors
The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-nave smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …
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- 16 Feb, 2024
- 1 location
Asian Diabetes Outcomes Prevention Trial
The aim of this study is to identify patients with DM at high risk of CVD using elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125pg/mL), and (2) intensify therapy using renin-angiotensin system (RAS) antagonists, beta-blockers and sodium glucose co-transporter-2 inhibitors (SGLT2i) for primary prevention of cardiovascular events in this high-risk …
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- 16 Feb, 2024
- 1 location
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Design Participants will be screened with: blood tests physical exam documentation of disease confirmation or tumor biopsy electrocardiogram to evaluate the heart review of their medicines and their ability to do their normal activities Participants will take metarrestin by mouth until they cannot tolerate it or stop to benefit from …
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- 16 Feb, 2024
- 1 location
Electrocardiogram in General Practice : the EGG Study
Existing resources to assist interpretation of ElectroCardioGram (ECG) in general practice provide specialized and comprehensive reading based on pathologies and ElectroCardioGram (ECG) signs rather than ElectroCardioGram (ECG) indications.
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- 16 Feb, 2024
- 1 location
Determination of Diastolic Dysfunction by Single Lead Electrocardiogram
A spectral analysis of the electrocardiogram will be performed using a continuous wavelet transform. The result of this study will be the identification of ECG parameters that will correlate with LV diastolic dysfunction.
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- 16 Feb, 2024
- 1 location
Testing a Wearable Monitor for Fetal Heart Rate Estimation Fetal Movement and Uterine Activity Detection
Owlet Baby Care, Inc. has developed a wearable fabric band pregnancy monitor, to be worn around the maternal abdomen incorporating electrocardiogram sensors. The purpose of this proposed test is to collect overnight "at-home" fetal ECG recordings on women during the second half of pregnancy using the pregnancy monitor.
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- 16 Feb, 2024
- 1 location
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