The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Tang-Du Hospital
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Updated on 16 February 2024
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traumatic brain injury
coagulopathy

Summary

The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.

Description

Uncontrolled hemorrhage after trauma is the leading cause of death. The mechanism of secondary coagulation dysfunction after trauma is special and complex, which has not been fully explained, leading to limited treatment and prevention methods. Coagulation disorders caused by traumatic brain injury is a systemic manifestation of local injury, which can activate platelets and promote platelet aggregation, activate thrombin, and promote the production of fibrin, leading to the formation of thrombosis. However, in non-injured areas, pro-coagulant molecules from damaged brain tissue reach the body through the broken blood-brain barrier, and also activate platelets and thrombin, promoting the formation of blood clots. Lipid peroxidation products are closely related to the occurrence of coagulation dysfunction. The effects lipid peroxidation products on platelets, thrombin and anticoagulant pathways may be a novel mechanism of secondary coagulation dysfunction in traumatic brain injury.

Details
Condition Brain Injury, Brain Injury, Coagulopathy, Brain Injuries, Traumatic
Age 18years - 80years
Clinical Study IdentifierNCT04274777
SponsorTang-Du Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

The interval between injury and admission is less than 24 hours
Age>18yrs and age<80yrs
Non-head abbreviated injury score < 3
Did not undertake treatment before enrollment
Informed consent to participate in the study

Exclusion Criteria

Take anticoagulants or antiplatelet drugs
Smoking history
Hemorrhagic or ischemic cerebrovascular disease occurred within six months
Other systemic diseases: uremia, cirrhosis, malignant tumor, etc
Patients with severe mental illness who are unable to communicate when diagnosed
Patients who refused follow-up
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