Low Dose Radiotherapy for COVID-19 Pneumonitis

  • STATUS
    Recruiting
  • participants needed
    41
  • sponsor
    Hospital San Carlos, Madrid
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Updated on 5 August 2020
See if I qualify
cytokines
inflammatory response
pao2
FIO2
x-rays
pneumonia
d-dimer
chest x-ray
pet/ct scan
SARS
chest ct
fraction of inspired oxygen (fio2)
acute respiratory syndrome (sars)

Summary

SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to its high rate of infection and the high morbidity and mortality.

The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting the immune response. Low dose radiotherapy (LD-RT) ( 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1 or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of LD-RT for SARS-CoV-2.

Details
Condition COVID19
Age 60years - 100years
Treatment Radiotherapy
Clinical Study IdentifierNCT04420390
SponsorHospital San Carlos, Madrid
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 60 years
COVID19 + confirmed by PCR
Thoracic imaging study (chest X-ray, chest CT or PET-CT), compatible with lung involvement
Phase II or lung phase without any improvement with pharmacological treatment
Phase III or hyper-inflammatory phase without any improvement with pharmacological treatment
Poor clinical and functional respiratory evolution: > 30 breaths / minute, SpO2 <93%, PaO2 / FiO2 <300\
D-dimer> 1000 ng / mL or rising, ferritin> 1000 ng / mL, PCR> 10 mg / dL or double than before

Exclusion Criteria

Severe comorbidities that could hamper the radiation treatment
Clear my responses
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cytokines
inflammatory response
pao2
FIO2
x-rays
pneumonia
d-dimer
chest x-ray
pet/ct scan
SARS
chest ct
fraction of inspired oxygen (fio2)
acute respiratory syndrome (sars)

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