Found 33 clinical trials
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs (KYANITE-1)
The Sponsor is developing KB707, a replication-defective, non-integrating herpes simplex virus type 1 (HSV-1)-derived vector designed to stimulate an anti-tumor immune response through the production of cytokines within the local tumor microenvironment in the lungs. KB707 is administered via nebulization, delivering the therapy directly through the airways to the lungs …
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- 12 Dec, 2025
Redefining BMI: The Body, Mind, and Inflammation Trial
Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in reducing adiposity, as well as improving …
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- 08 Dec, 2025
- 1 location
A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients
The primary purpose is to evaluate the safety and tolerability of OP-101 and secondary purpose is to determine the effect of OP-101 reducing proinflammatory cytokines after a single dose in severe COVID-19 Patients.
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- 05 Aug, 2020
CANnabiDiol for CoviD-19 pATiEnts With Mild to Moderate Symptoms
The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: i) decrease viral load; ii) modify inflammatory parameters, such as cytokines, measured from serum; iii) reduce clinical and emotional symptoms through daily …
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- 01 Feb, 2023
- 1 location
Low Dose Radiotherapy for COVID-19 Pneumonitis
Low dose radiotherapy (LD-RT) ( 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1 or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% …
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- 05 Aug, 2020
Role of Inflammasomes in COVID-19 Disease
Activating multiprotein complexes called inflammasomes, which cause pro-IL-1 and pro-IL-18 to be transformed into active pro-inflammatory cytokines are one of these pathways. The central role of inflammasomes in the secretion of these pro-inflammatory cytokines deserves an in-depth study of their activation during COVID-19, whereas the inadequate inflammatory response appears to …
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- 16 Feb, 2024
- 2 locations
Clinical Study of DC-CIK Cells as a Post-remission Treatment for Malignant Tumors
Screening stage Evaluation of disease Grouping of patients Infusion of cells Surveillance of adverse effect
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- 16 Feb, 2024
- 1 location
Stress Management and Biological Age in Breast Cancer Patients.RCT
Intense stress has harmful effects on the body, contributing to various disorders. Breast cancer patients experience a build-up of stress due to their diagnosis and treatments. Stress can cause epigenetic changes in a cellular level (such as accelerated increase in biological age) that may negatively affect oncological treatments. This study …
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- 03 Oct, 2023
- 13 locations
Test-Trial-29-Aug
Intense stress has harmful effects on the body, contributing to various disorders. Breast cancer patients experience a build-up of stress due to their diagnosis and treatments. Stress can cause epigenetic changes in a cellular level (such as accelerated increase in biological age) that may negatively affect oncological treatments.This study aims …
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- 08 Sep, 2023
- 1 location