Switch of Renin-Angiotensin System Inhibitors in Patients With Covid-19

  • STATUS
    Recruiting
  • participants needed
    240
  • sponsor
    University of Sao Paulo
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Updated on 16 February 2024
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hypertension
antihypertensive drugs
angiotensin
chest ct
serologic test

Summary

The SWITCH-COVID trial will randomize patients with COVID-19 that are currently using renin-angiotensin system inhibitors for treating hypertension to maintain the therapy during in-hospital stay or switch the therapy to other antihypertensive classes.

Description

Patients eligible for the study, after signing informed consent will be randomized 1:1 for maintenance of renin-angiotensin system inhibitors or switching the antihypertensive therapy for other classes according to a pre-specified protocol.

Patients are going to be followed during hospital stay for evaluation of clinical endpoints. Also blood and urine samples will be acquired for evaluation of renin-angiotensin system activation.

Details
Condition COVID19, Angiotensin II Receptor Antagonist Adverse Reaction
Age 18years - 80years
Treatment Renin-angiotensin system inhibitors
Clinical Study IdentifierNCT04493359
SponsorUniversity of Sao Paulo
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Hypertension in use of renin-angiotensin system inhibitors
Confirmed COVID-19 infection by rt-PCR, serology tests or typical clinical presentation and chest CT
Symptoms onset < 96h
Need for hospitalization

Exclusion Criteria

Heart failure
Previous cerebrovascular disease
Previous myocardial infarction
Blood pressure > 180 x 100 mmHg
Need for 3 or more anti-hypertensive classes
Use os spironolactone
Severe pulmonary disease
Contraindication for using other anti-hypertensive classes (calcium channel blockers, hydralazine, diuretics or nitrates)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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