This is a Phase 1/2, open label, multiple cohort study to assess the safety and preliminary
efficacy of SAR445877 as a monotherapy for participants aged at least 18 years with advanced
unresectable or metastatic malignancies.
The study will include 2 parts:
A dose escalation Part 1: for finding the recommended dose(s) of SAR445877 in a monotherapy
given every 2 weeks (Q2W) or weekly (QW).
A multicohort dose expansion Part 2: for the assessment of safety and preliminary efficacy of
SAR445877 in monotherapy (2 dose levels will be tested in at least 1 indication as
applicable).
Approximately 240 participants will be enrolled to the study intervention:
For Part 1: approximately 75 participants, For Part 2: up to 30 participants will be enrolled
in each cohort per dose level for a total of approximately 165.