recurrent head and neck squamous cell cancer Clinical Research Trials

Found 5 clinical trials

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Multi-country trial
Phase 2
For Seniors
For adults
Recruiting in 100s
Interventional Study
all
Recruiting

Study of Intratumoral (IT) MK-1454 in Combination With Intravenous (IV) Pembrolizumab (MK-3475) Compared to IV Pembrolizumab Alone as the First Line Treatment of Metastatic or Unresectable Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) (MK-1454-002)

The purpose of this study is to assess the efficacy and safety of intratumoral (IT) MK-1454 in PLUS pembrolizumab (MK-3475) compared to pembrolizumab alone as a first line treatment of adults with metastatic or unresectable, recurrent head and neck squamous cell carcinoma (HNSCC). The primary study hypotheses are that IT …

hiv test

recurrent head and neck squamous cell carcinoma

biomarker analysis

HIV Infection

pembrolizumab

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16 Feb, 2024
18 locations

Phase 2
For Seniors
For adults
Recruiting in 100s
Interventional Study
all
Recruiting

Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)

Chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma is palliative and usually platinum based, and the patients often present with poor physical condition. Consequently, many of them are not able to withstand a platinum-based chemotherapy. The addition of taxanes to the armamentarium of drugs improve the outcome …

ct scan

corticosteroids

major surgery

paclitaxel

carcinoma

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16 Feb, 2024
20 locations

Phase 1
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Recruiting

CIML NK Cell in Head & Neck Cancer

This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the following drugs and biologics: CIML NK donor cells IL-15 superagonist Ipilimumab

ejection fraction

oxygen saturation

corticosteroids

advanced head and neck cancer

systemic corticosteroid therapy

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16 Feb, 2024
1 location

Phase 1
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Recruiting

Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer

Giving bintrafusp alfa and stereotactic body radiation therapy may help to control recurrent head and neck squamous cell cancer.

ct scan

head and neck carcinoma

cancer

recurrent head and neck squamous cell cancer

stereotactic body radiation

0 views
16 Feb, 2024
1 location

Phase 2
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Recruiting

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

This is a Phase II treatment, non-randomized, open label clinical trial to study the efficacy of the Cetuximab when administered as single agent in recurrent/ metastatic head and neck squamous cell carcinoma after the failure or intolerance of immuno-oncology or immuno-oncology combined with chemotherapy.