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Found 3 clinical trials
Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

This phase I/II trial studies the side effects and best dose of avelumab with M6620 in treating patients with deoxyribonucleic acid (DNA) damage repair (DDR) deficient solid tumors that have spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable).

HIV Infection
monoclonal antibody therapy
opportunistic infection
infertility
BARD1
  • 0 views
  • 16 Feb, 2024
  • 1 location
Niraparib/TTFields in GBM

Evaluating the efficacy and safety of niraparib and Tumor-Treating Fields (TTFields) in recurrent glioblastoma (GBM).

recurrent glioblastoma
renal function
MRI
renal function test
karnofsky performance status
  • 0 views
  • 16 Feb, 2024
  • 1 location
Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

The purpose of this research is to study the role of a DNA repair pathway in prostate cancer, specifically in response to administration of radium-223, an FDA-approved drug known to cause DNA damage to cancerous cells. Understanding how defects in the DNA repair pathway affects radium-223 treatment of prostate, may …

stage iv prostate cancer ajcc v8
carcinoma
biospecimen collection
prostate-specific antigen
metastasis
  • 0 views
  • 16 Feb, 2024
  • 1 location