Found 953 clinical trials
Selfcare MAnagement InteRvenTion in COPD (SMART COPD)
To evaluate whether a digital support and communication platform for COPD patients after 6 months provides: Decreased breathlessness on the basis of modified medical research council dyspnea scale [mMRC] Improved health status and symptom relief based on COPD assessment scale [CAT] Improved quality of life based on EQ-5D Reduction in …
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- 05 Aug, 2020
Quality-of-Life Management for COPD Patients
The investigators aim to investigate the effects of a telemonitoring and chatbot-based application of "Living well with COPD" (CAir) on health-related quality-of-life in patients with COPD.
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- 05 Aug, 2020
Lorlatinib Combinations in Lung Cancer
This research study is evaluating Lorlatinib in combination with Crizotinib or Binimetinib as a possible treatment for either anaplastic lymphoma kinase (ALK)-positive lung cancer or ROS1-positive lung cancer. This research study involves three study drugs. Lorlatinib Binimetinib Crizotinib
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- 16 Feb, 2024
- 2 locations
Doxapram Therapy in Preterm Infants (DOXA Trial)
This study compares doxapram to placebo and hypothesizes that doxapram will protect preterm infants from both invasive ventilation (and related lung disease) and AOP related oxygen shortage (and related impaired brain development).
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- 16 Feb, 2024
- 18 locations
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs (KYANITE-1)
Combination regimens with a selected (fixed) dose of KB707 are being evaluated in subjects with advanced or metastatic non-small cell lung cancer (NSCLC). Subjects in Cohorts 5 and 6 are receiving inhaled KB707 once every 2 weeks (q2w), delivered in combination with Keytruda once every 6 weeks.
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- 12 Dec, 2025
Clinical Utility of Liquid Biopsy in Brigatinib ALK+ Patients
Chemotherapy-nave patients with EML4-ALK rearrangement and with locally advanced or metastatic non-small cell lung cancer patients will be selected. Patients enrolled in the study will receive brigatinib 90mg for the first 7 days (D 1-7 at cycle 1) and then 180mg daily thereafter for QW4 cycles of duration (28 days …
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- 16 Feb, 2024
- 15 locations
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis G3. The potential advantage of the dose escalation planned in this study is the delivery of an ablative dose to radically treat patients with inoperable local relapse, without …
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- 16 Feb, 2024
- 1 location
Monitoring COVID-19 Patients' Lung Fluid Using Impedance Technique
Today, a chest X-ray is the only practical way to check the degree of lung accumulation. However, X-Ray has many limitations and disadvantages. Lung impedance technology allows simple lung fluid monitoring, and found to be effective in HF patients who suffer from a similar problem.
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- 05 Aug, 2020
Lung Ultrasound Assessment of Fluid Overload in Haemodialysis Patients (EP8SH)
It can estimate pulmonary congestion. The aim of the study is to evaluate the lung ultrasound using "8 sites" score accuracy for estimating fluid overload of patients before hemodialysis session.
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- 24 Nov, 2021
- 1 location
A Trial of Adding Lung Protective Strategies to Existing Enhanced Recovery After Surgery (ERAS) Protocols and Its Effects on Improving Post-Operative Lung Function
The objective of this study is to determine whether the addition of lung protective strategies to existing enhanced recovery after surgery (ERAS) protocols for colorectal surgeries and hepatobiliary surgeries will improve post-operative lung function.
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- 05 Aug, 2020