Found 1429 clinical trials
Effect of MEDiterranean Diet on the microBIOME of Individuals With Type 2 Diabetes
Dysbiosis of gut microbiota is associated with the pathophysiology of type 2 diabetes. Mediterranean diet has been indicated as a dietary pattern that promote the integrity of gut barrier and that has positive impact in the metabolic control of subjects with type 2 diabetes.
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- 16 Feb, 2024
- 1 location
Multi-CAR-T Cells Targeting B Cell Lymphomas
This study aims to evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting B cell surface molecules including CD19 and alternative CARTs as booster and consolidation treatment for patients with highly resistant B cell lymphomas, including primary mediastinal B cell lymphoma (PMBCL) …
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- 16 Feb, 2024
- 3 locations
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2
This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow …
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- 05 Aug, 2020
Enzalutamide Treatment in COVID-19
Enzalutamide is an antiandrogen inhibiting the expression of androgen regulated proteins, such as TMPRSS2. The aim of this trial is to evaluate a possible beneficial effect of short-term enzalutamide treatment of COVID-19 patients.
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- 05 Aug, 2020
Intergenerational Program for Social Isolation and Loneliness in Older Adults Discharged From the Emergency Department (SIL)
Social isolation and loneliness worsens older adults' risk of dementia, quality of life, and death as much as smoking. Older adults are more likely to use emergency services and are also more likely to experience social isolation and loneliness than younger people.
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- 23 Aug, 2023
- 1 location
Intervention for Fluency Difficulty
The focus of the study is to identify children with word-finding difficulty and other speech and communication difficulties such as stuttering, a procedure referred to as screening. Ideally, investigators want to screen all children in the reception classes in the schools with which investigators work.
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- 16 Feb, 2024
- 1 location
Scar Resection and Reconstruction With Integra and Split Skin Grafts in Patients With Non-Suicidal Self-Inflicted Scars
Non-suicidal self-inflicted (NSSI) scars can act as a physical reminder of previous self-inflicted self-harm, thereby not only worsening the symptoms of depression and self-doubt but also leading to recurrent self-infliction and social exclusion.
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- 05 Aug, 2020
Effect of Non-invasive Neurostimulation on Variability OF HEART RATE IN PATIENTS WITH HEART FAILURE. (HD-tDCS)
This study is a clinical trial, and may also be referred to as a "before and after" study, in which all subjects receive the same treatment and their condition is checked before initiation and after various times of treatment.
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- 14 Jul, 2023
- 1 location
Safety and Preliminary Efficacy of Combination Therapy for the Treatment of Acne Vulgaris
Use of MCT alone or in combination with current successful treatment such as blue light phototherapy (BLP), may hold promise for acne treatment
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- 06 Oct, 2023
- 1 location
Respiratory Muscle Training (RMT) in ALS
Participants will be stratified into 2 groups based on baseline inspiratory muscle strength as determined by maximum inspiratory pressure (MIP): six participants with minimal to no respiratory weakness (i.e., MIP 70% predicted) and six participants with mild to moderate inspiratory weakness (i.e., MIP 40-70% predicted).
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- 16 Feb, 2024
- 1 location