Found 500 clinical trials
Compare the Impact of Hemofilters and Hemodialyzers on Cytokine Removal During Cardiopulmonary Bypass in Pediatric Cardiac Surgery
Cardiopulmonary bypass (CPB) allowed the correction of several congenital heart diseases such as intracardiac malformations, but it is well known that this is not a harmless procedure because it can lead to a systemic inflammatory response syndrome (SIRS), with activation of complement, cytokines, coagulation, and fibrinolysis pathways.Due to economic causes, …
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- 04 Feb, 2025
Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia
Vitamin C is significant to human body and plays a role in reducing inflammatory response and preventing common cold. In addtion, a few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections.
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- 16 Feb, 2024
- 1 location
Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19
Infection with SARS-CoV-2 causes human COVID-19 (HCoV-19). The infection is associated with a deleterious inflammatory response and a prothrombotic state in addition to tissue damage from direct viral entry and proliferation. Dipyridamole has anti-platelet and anti-inflammatory effects.
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- 16 Feb, 2024
- 1 location
Dexamethasone for COVID-19 Related ARDS: a Multicenter Randomized Clinical Trial
There is compelling data indicating that there is an excessive inflammatory response in some patients with COVID-19 leading them to develop ARDS that can be severe with a very poor prognosis. Many of these patients require very long mechanical ventilation times to survive, which have led to the collapse of …
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- 16 Feb, 2024
- 3 locations
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.
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- 16 Feb, 2024
- 1 location
A Study of COVID 19 Convalescent Plasma in High Risk Patients With COVID 19 Infection
Purpose of Study The purpose of this study to evaluate, the effectiveness of convalescent plasma in combatting the symptoms and effects of the coronavirus disease, COVID-19. Beyond supportive care, there are no proven treatment options for COVID-19.
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- 05 Aug, 2020
Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care (active) vs. standard of care alone (SoC), the control group. The gammaCore (nVNS) treatments will be used acutely …
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- 16 Feb, 2024
- 1 location
The CASCADE Study - Measures of Complement Activation and Inflammation in Patients With Covid-19
In this study the investigators will measure different parts of the inflammation process to better understand what may be causing severe disease and to see if there may be benefits from a new treatment to reduce inflammation
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- 16 Feb, 2024
- 1 location
Immune Response and Risk of Serious Infection to SARS-Cov2
One hypothesis is that it is related to an inappropriate inflammatory response rather than a direct cytopathic effect of the virus. The objective of this study is to measure the intensity of the T lymphocyte response in patients hospitalized for Cov2 SARS infection in order to determine whether the intensity …
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- 16 Feb, 2024
- 1 location
COVID-19: Study of INFLAmmasome and PLAtelets Functions
COVID-19 pandemic is a severe viral sepsis characterized by the occurrence of Acute respiratory distress syndrome (ARDS) whose pathophysiology is little described
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- 05 Aug, 2020