Found 1431 clinical trials
Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B With or Without Inhibitory Antibodies to Factor VIII or IX
Primary Objective: To characterize the long-term safety and tolerability of fitusiran Secondary Objectives: To characterize the long-term efficacy of fitusiran as assessed by the frequency of: Bleeding episodes Spontaneous bleeding episodes Target joint bleeding episodes To characterize the effects of fitusiran on health-related quality of life (HRQOL) measures in participants …
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- 04 Dec, 2020
- 41 locations
Nasopharyngeal Carriage of S. Pneumoniae
This nasopharyngeal (NP) carriage surveillance study was requested by the European Agency for the Evaluation of Medicinal Products as a post-licensing commitment to determine whether the use of the pneumococcal conjugate vaccines (PCVs) including 7 then 13 valents (introduced in 2001 and 2010, respectively) caused a shift in the distribution …
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- 16 Feb, 2024
- 1 location
Percutaneous Endoscopic Decompression for Lumbar Canal Stenosis
There are still some controversial points of LSS decompression under percutaneous endoscope surgery, such as the range of decompression, choice of approach, postoperative spinal stability, learning curve, surgical safety, long-term effects of endoscopic treatment of restenosis at adjacent segments after fusion surgery.
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- 16 Feb, 2024
- 1 location
Role of Lymphnode Dissection in Men With Prostate Cancer Treated With Radical Prostatectomy
The risks include prolonged surgery duration, injury of vessels and nerves, as well as disorders of lymphatic circulation after surgery. Moreover, formation of lymphoceles (accumulation of lymph fluid in the tissue) are common, which may result in soft tissue swelling, thrombosis, inflammation and additional surgical procedures.
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- 16 Feb, 2024
- 1 location
Stress Management and Biological Age in Breast Cancer Patients.RCT
Breast cancer patients experience a build-up of stress due to their diagnosis and treatments. Stress can cause epigenetic changes in a cellular level (such as accelerated increase in biological age) that may negatively affect oncological treatments. This study aims to investigate the effect of stress management, specifically the Pythagorean Self-Awareness …
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- 03 Oct, 2023
- 13 locations
Host Genome Methylation: a Screening Tool in Anal Cancer Detection (AMethysT)
The development of biological markers could enable only patients at high risk of high-grade dysplasia/anal cancer to be referred for HRA.As part of the AIN3 cohort, we demonstrated that the markers ZNF582 and ASCL1, studied on anal smears taken when patients were included in the cohort, showed a significantly higher …
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- 04 Feb, 2025
Test-Trial-29-Aug
Breast cancer patients experience a build-up of stress due to their diagnosis and treatments. Stress can cause epigenetic changes in a cellular level (such as accelerated increase in biological age) that may negatively affect oncological treatments.This study aims to investigate the effect of stress management, specifically the Pythagorean Self-Awareness Intervention, …
- 0 views
- 08 Sep, 2023
- 1 location
Testing the Efficacy of the Ability School Engagement Partnership Program (ASEP)
., delinquency), this trial will also test the capacity of the program to improve collaboration between the schools and police and also monitor young participants' future life outcomes, such as future welfare dependence.
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- 16 Feb, 2024
- 1 location
Families Children and Teachers Thriving Together
The study is conducted within the context of the NYC Department of Education (DOE) Pre-K Thrive initiative. As part of this initiative, the Center for Early Childhood Health and Development (CEHD) at NYU Langone Health is implementing services to strengthen family engagement and support parents and teachers in creating safe, …
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- 16 Feb, 2024
- 1 location
Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"
The COVID-19 pandemic has been characterized by high morbidity and mortality, especially in certain subgroups of patients. To date, no treatment has been shown to be effective in controlling this disease in hospitalized patients with moderate and / or severe cases of this disease. Hydroxychloroquine and lopinavir / ritonavir have …
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- 16 Feb, 2024
- 4 locations