Found 1695 clinical trials
Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human volunteers.
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- 08 Aug, 2025
A Study To Investigate The Safety Tolerability Pharmacokinetics And Pharmacodynamics Of RO7248824 In Participants With Angelman Syndrome
This is a Phase I, multicenter, non-randomized, adaptive, open label, multiple ascending, intra-participant, dose-escalation study using IT administration to investigate the safety, tolerability, PK and PD of RO7248824 in participants with AS. Two linked sets of dose escalation cohorts are planned based on two different age groups, namely participants with …
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- 05 Aug, 2020
Strength Training in Female Runners With Patellofemoral Pain
This injury occurs twice as frequently in females and is often associated with weakness of the muscles of the thigh and hip, as well as altered running form.
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- 16 Feb, 2024
- 1 location
Effects of Internet-based ERITA Added to TAU in Young People With Non-Suicidal Self-Injury (TEENS) Feasibility Trial
We aim to assess the feasibility of methods, procedures, and safety of internet-based Emotion Regulation Individual Therapy for Adolescents (ERITA) as add on to treatment as usual (TAU) in 13-17-year-old patients with non-suicidal self-injury referred to psychiatric services.
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- 16 Feb, 2024
- 1 location
A Trial to Evaluate the Potential Benefit of Adjuvant Chemotherapy for Small Bowel Adenocarcinoma
An open-label, randomised, controlled, multi-centre, trial with disease free survival as the primary end point. The worldwide collaboration is referred to as GLOBAL BALLAD and consists of a number of individual parallel prospective studies addressing the same objectives with similar designs brought together under the framework of the International Rare …
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- 16 Feb, 2024
- 9 locations
Effects of Almond Consumption on the Human Gastrointestinal Microbiota and Metabolic Health
The proposed work will investigate the effect of almond consumption as a snack on human gastrointestinal microbiota and on metabolic health.
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- 16 Feb, 2024
- 1 location
4SCAR-T Therapy Post CD19-targeted Immunotherapy
This study will evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells (4SCAR-T) targeting CD19-negative B-ALL that express alternative surface antigens such as CD22, CD10, CD20, CD38, and CD123, as many patients relapse after anti-CD19 immunotherapy. Clinical response and optiminzation of a standardized …
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- 05 Aug, 2020
Low Dose Radiotherapy for COVID-19 Pneumonitis
Low dose radiotherapy (LD-RT) ( 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1 or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% …
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- 05 Aug, 2020
The Influence of a Perturbation Training on Balance Recovery of Old Adults: a Randomized Controlled Trial
We also hypothesize that brain function as seen in MRI will be improved in both training methods, more in the random training method. As far as we know, there is a lack of studies investigating the learning effect of random vs.
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- 16 Feb, 2024
- 3 locations
Study of Venetoclax in Combination With Azacytidine in AML Patients Selected Using Ex Vivo Drug Sensitivity Screening
The exploratory study will aim to find novel combinations for overcoming resistance as well as finding/validating biomarkers for both sensitivity and resistance.
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- 16 Feb, 2024
- 1 location