Found 442 clinical trials
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function. This study will be longitudinal, with a short-term double-blind placebo-controlled phase consisting of 20 rTMS sessions and a long-term phase, consisting of 2 weekly sessions for 12 …
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- 03 Jan, 2024
- 1 location
Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis
Transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebral excitability in several neurodegenerative disorders and modulate intracortical connectivity measures. In this randomized, double-blind, sham-controlled study followed by an open-label phase, the investigators will evaluate whether a repetition of two-weeks' treatment with bilateral motor …
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- 16 Feb, 2024
- 1 location
testslug trial title
Up to 25% of patients manifest a chronic course of illness, resulting in a need for additional treatment options. The DiSCoVeR trial is a multi-site, double-blind, sham-controlled, proof-of concept randomized controlled trial (RCT). The study aims to investigate the feasibility and efficacy of an innovative, combined treatment approach, incorporating transcranial …
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- 09 Jul, 2021
Ginko Biloba Versus Desmopressin in Treatment of Children With Monosymptomatic Nocturnal Enuresis
Since Dimson in 1977 reported on the effects of desmopressinl" several double blind, placebo controlled studies have shown the efficacy of the drug often with rapid effect but also often with immediate relapse after ending treatment.
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- 07 Apr, 2025
Mobile App as a Guide to Exercises for Patients With Chronic Stroke
Objectives: To analyze adherence to physical rehabilitation by mobile App and to evaluate the effectiveness of lumbopelvic stability exercises performed at home with the App. Material and methods: Randomized controlled single blind pilot study (n = 30). Participants with Stroke (<6 months) will be randomized between two groups (App for …
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- 16 Feb, 2024
- 1 location
Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging
The investigators will use a dual-site, 12- week drug intervention trial performed in a double-blind, placebo-controlled manner on 148 subjects recruited from two separate sites (Oklahoma Medical Research Foundation (OMRF) and University of Illinois Urbana-Champaign (UIUC)).
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- 16 Feb, 2024
- 2 locations
Implementation of an Early Rehabilitation Program for the Patient With Lung Transplantation: From the ICU to Home.
Objectives: To introduce an early rehabilitation program in the ICU after PT to see if there is an improvement in functionality, an increase in strength and muscle mass, an improvement in the strength of the respiratory muscles and a shorter hospitalization time in the ICU and in the ward. Methodology: …
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- 16 Feb, 2024
- 1 location
The Effect of Chronic Pain on Delay Discounting in Methadone Patients
The epidemic of opioid overdose deaths continues to rise, killing more persons in 2017 than HIV/AIDS at the height of that epidemic. Medication assisted treatment, including methadone and buprenorphine, is the standard of care for the treatment of opioid use disorder (OUD). However, chronic pain can reduce treatment efficacy during …
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- 16 Feb, 2024
- 1 location
Based on the "Brain-gut -Lung" Axis the Mechanism of Treating Stroke-associated Pneumonia by Tong-Fu-Xing-Shen Capsules
The regulation of T cells / IL-17 pathway mediated by the intestinal flora has become a new molecular target for the treatment of SAP. To test whether TFXSCs are through the pathway as above, this protocol describes an ongoing randomized controlled clinical trial, based on the theory of traditional Chinese …
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- 16 Feb, 2024
- 1 location
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
Background The retina is a thin layer of tissue at the back of the eye. Retinal disease usually reduces a person s mobility because it affects how he or she moves through familiar and unfamiliar environments. Researchers want to see if a virtual reality (VR) tool can provide an easier …
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- 16 Feb, 2024
- 2 locations