Found 373 clinical trials
Safety Tolerability and Pharmacokinetics of Inhaled Nanoparticle Formulation of Remdesivir (GS-5734) and NA-831
The clinical study is designed to evaluate the safety, tolerability and pharmacokinetics of inhaled nanoparticle nanoparticle formulation of Remdesivir (GS-5734) alone and in combination with NA-831 in 48 healthy volunteers.
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- 16 Feb, 2024
- 1 location
Study of ATI-2138 in Adult Participants With Moderate to Severe Atopic Dermatitis
This is a Phase 2 open label study of ATI-2138 in participants with moderate to severe atopic dermatitis.
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- 09 Sep, 2024
- 1 location
Transcranial Direct Current Stimulation for Cognitive Improvement in Parkinson's Patients (tDCS) (tDCS)
The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left dorsolateral prefrontal cortex (LDLPFC) will induce long-lasting effects in improving cognitive function and reducing cognitive fatigue and fatigability in PD patients.
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- 22 Jul, 2024
Effect of Ketone Esters in Parkinson's Disease
Ketones esters have shown to improve mitochondrial function and are currently use to enhanced functional performance. As Mitochondrial dysfunction is one of the proposed mechanism of neuronal injury in Parkinson's disease, the study aims to assess the tolerability,side effects and effect of oral ketone esters in Patients with Parkinson's disease.
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- 05 Aug, 2020
Isoleucine Intake and Intermediary Metabolism in Type 2 Diabetes
The primary objective of this study is to determine the mechanism of reduced branched-chain amino acid (BCAA) oxidation to propionyl CoA and isoleucine intake can affect TCA cycle function in obese insulin resistant T2D. We will test the hypotheses that isoleucine and valine oxidation to propionyl CoA is reduced and …
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- 16 Feb, 2024
- 1 location
Isolating and Exploiting the Mechanisms That Link Breakfast and Human Health - Intervention
Following the establishment of causal links between breakfast consumption, the individual components of energy balance, and health it is now important to examine and target the underlying biological mechanisms involved to maximise potential health benefits. To begin investigating the outlined mechanisms healthy, non-obese participants will be recruited to take part …
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- 05 Aug, 2020
Assesment of Multiomics Profiles in Health and Disease.
This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.
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- 16 Feb, 2024
- 1 location
Early Onset Alzheimer's Disease Genomic Study
The purpose of this study is to collect samples from patients with Early-Onset Alzheimer's disease (AD) and their immediate family members for molecular analysis. Samples will be studied in order to understand how molecular changes in the body are related to the development of the disease.
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- 16 Feb, 2024
- 1 location
Blood Biomarker of Alzheimer's Disease (AD)
Currently, no cures or disease modifying therapies exist for Alzheimer's disease (AD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations.
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- 16 Feb, 2024
- 1 location
Gut Microbiota and Alzheimer's Diseases
The investigator will perform clinical studies to test the hypothsis that participants who had Alzhemer's disease will have different gut microbiota in the feaces as compared to participants who did not have Alzhemer's disease, as well as compared to their spouse.The investigators plan to perfoem the studies in 150 participants …
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- 16 Feb, 2024
- 1 location