Found 366 clinical trials
Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases
To observe the quality of life (QOL) and to report on toxicity and outcome parameters after the (repeated) use of local ablative therapy (LAT) i.e. stereotactic radiotherapy (SRT) for patients with multiple (4-10) brain metastases
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- 16 Feb, 2024
- 1 location
Can Gait Analysis and Ultrasound Detect a Change in Calf Musculature in Children With Cerebral Palsy?
ORLAU is a clinical department of the Robert Jones and Agnes Hunt Orthopaedic Hospital. We treat patients with a wide range of movement disorders affecting their walking or arm function. One of the most common gait issues we see is toe-walking, this is most prevalent in those patients with cerebral …
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- 16 Feb, 2024
- 1 location
Hypertension Management in Family Practice
High blood pressure is the greatest threat to the global burden of disease, contributing to an estimated 9.4 million deaths a year. Cardiovascular disease morbidity and mortality are positively correlated with the degree of elevation of blood pressure, without any evidence of a threshold down to at least 115/75 mm …
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- 08 Nov, 2022
- 3 locations
Prospective Validation and Application of an Artificial Intelligence-based Model for Evaluating the Efficacy of Breast Cancer Patients After Neoadjuvant Therapy
Breast cancer has become the world's number one cancer. While its therapeutic efficacy is increasing, how to achieve non-invasive evaluation of the efficacy of neoadjuvant therapy (NAT) for breast cancer patients and thus avoid surgery has become a bottleneck problem that needs to be broken through in clinical diagnosis and …
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- 20 Feb, 2025
- 1 location
Creation of a Monocentric Cohort of Patients Treated for Acne at the Nantes University Hospital (COPACNE)
With 24 million results associated with Google's searchon keywords "severe acne", Pr Dreno's team understand better thatthis disease, which affects many French people, is a real concern of Public Health and not a "forced evil" of the adolescent period, which will eventually resolve itself. Acne does not affect the vital …
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- 31 May, 2024
- 1 location
Tissue Models for Liver Disease (TIMOLD)
The human immune response to bacterial and viral local and systemic infection are fairly well understood, but we lack details on the earliest phases. Better knowledge of these events would be important for the prevention and treatment of severe bacterial or viral disease. From models of infection, we have data …
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- 24 May, 2022
- 1 location
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing Patients
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output. By consequence, it is now recommended to predict the fluid response (fluid or preload responsiveness) before infusing them. In this protocol, the investigators will …
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- 31 Jul, 2024
Transcriptional and Epigenetic Program of PCOS Women (EPIC)
The main goal is to reveal differences in global gene expression in two different adipose tissue (AT) depots of females with and without polycystic ovary syndrome (PCOS) and how these are influenced by upstream epigenetic markers
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- 23 Mar, 2022
- 2 locations
Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation (MUSCLE+)
Facioscapulohumeral dystrophy (FSHD) is one of the most common hereditary neuromuscular disorders (NMD), with an estimated prevalence of 2000 patients in the Netherlands. Magnetic resonance imaging (MRI) and muscle ultrasound have contributed to an enhanced understanding of the pathophysiology of Facioscapulohumeral Muscular Dystrophy (FSHD). Previously, our group demonstrated the potential …
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- 30 Jan, 2024
- 1 location
A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
This study aims to identify and assess new CMR techniques that can improve current CMR protocols.
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- 16 Feb, 2024
- 1 location