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Effects of Almond Consumption on the Human Gastrointestinal Microbiota and Metabolic Health

The proposed work will investigate the effect of almond consumption as a snack on human gastrointestinal microbiota and on metabolic health.

Teaching Novel Values-Based Skills to Improve Long-Term Weight Loss

This NIDDK funded R01 project is a randomized controlled clinical trial to compare the efficacy of an intervention based on Acceptance and Commitment Therapy (ACT) and a Self-Regulation (SR) intervention on weight loss maintenance over a 30-month period. All participants will first complete a well-validated online weight loss intervention (months …

A Study to Test How Well Different Doses of BI 1356225 Are Tolerated by Men and Women Who Are Overweight or Obese.

The primary objective of this trial is to investigate safety and tolerability of BI 1356225 in male and female patients with overweight and obesity following oral administration of multiple rising doses per day over 28 days. Secondary objectives are the exploration of pharmacokinetics (PK) of BI 1356225 after multiple oral …

Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of IBI362 in Overweight or Obesity Subjects

This trial is conducted in China. The aim of this trial is to investigate Safety, Tolerability, PK and PD for Multiple Doses of IBI362 in Male and Female Subjects being Overweight or with Obesity.

Improving Insulin Sensitivity by Non-invasive Brain Stimulation

Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease. In recent studies, the hypothalamus was identified as part of a …

A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell transplant. This study may help researchers learn more about how adolescents and young adults …

Long-term Consumption of Resistant Starch Type-4 (RS4)

The primary objective of the current proposal is to determine the effectiveness of long-term consumption of Fibersym RW for improving blood lipids (including cholesterol) and body composition. The overall goal of this clinical research is to determine the potential effects that RS4 consumption may have on the prevention of obesity …

A Randomized Trial to Test an Acceptance-based Therapy Intervention Among Adolescent Girls With Overweight/Obesity

The purpose of this study is to investigate the effects of an acceptance-based therapy weight loss intervention compared with enhanced care for adolescents.

Exercise and Diet Counseling Program in Improving Quality of Life in Stage I-III Breast Cancer Survivors

This trial studies the benefits of an exercise and diet counseling program in improving quality of life in stage I-III breast cancer survivors. Exercise and diet counseling may help improve weight loss and relevant clinical and patient-reported outcomes in overweight or obese breast cancer survivors.