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Found 277 clinical trials
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A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)

The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.

psychiatric disorder
antidepressants
depressive disorder
psychotherapy
benzodiazepines
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  • 16 Feb, 2024
  • 36 locations
A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression

The main objectives of this trial are to evaluate the efficacy and safety of oral BI 1358894 compared to placebo over a 6-week treatment period in participants with Major Depressive Disorder (MDD) and with inadequate response to antidepressants (SSRI or SNRI) utilizing a decentralized clinical trial (DCT) model.

psychiatric disorder
serotonin and norepinephrine reuptake inhibitors
serotonin reuptake inhibitors
suicidal
suicide
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  • 16 Feb, 2024
  • 1 location
A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder

The purpose of the study is to evaluate the effect of seltorexant, compared to placebo, as an add-on medication to an antidepressant, on next-day driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) from an on-road driving test.

norepinephrine
desvenlafaxine
serotonin reuptake inhibitors
selective serotonin reuptake inhibitors
noradrenaline
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  • 16 Feb, 2024
  • 2 locations