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A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)

The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.

A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression

The main objectives of this trial are to evaluate the efficacy and safety of oral BI 1358894 compared to placebo over a 6-week treatment period in participants with Major Depressive Disorder (MDD) and with inadequate response to antidepressants (SSRI or SNRI) utilizing a decentralized clinical trial (DCT) model.

A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder

The purpose of the study is to evaluate the effect of seltorexant, compared to placebo, as an add-on medication to an antidepressant, on next-day driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) from an on-road driving test.

PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents

The study is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental health disorders. Using cluster …

tDCS Intervention on Motivational Anhedonia of Major Depressive Disorder

Study of tDCS intervention on motivational anhedonia of Major Depressive Disorder