waldenstrom's macroglobulinemia Clinical Research Trials

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Found 240 clinical trials

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Phase 2
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Oncology
Recruiting

Zanubrutinib Ixazomib and Dexamethasone in Patients With Treatment Naive Waldenstrom's Macroglobulinemia

This study aims to evaluate the efficacy of BTK inhibitor Zanubrutinib combined with Ixazomib and Dexamethasone (ZID) for the newly diagnosed Waldenstrom Macroglobulinemia. This ZID regimen will be given up to 24 months and stopped for observation. We propose this combination will improve the deep remission (VGPR) compared to single …

waldenstrom's macroglobulinemia

cytopenia

lymphoma

indolent lymphoma

remission

0 views
16 Feb, 2024
1 location

Phase 2
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Hematology
Recruiting

Ibrutinib + Venetoclax in Untreated WM

This study evaluates the safety and efficacy of Ibrutinib combined with Venetoclax (IVEN) in the treatment of adults diagnosed with Waldenstrom's macroglobulinemia (WM) cancer with a specific MYD88 gene mutation. This research study involves an experimental drug combination of targeted therapies.

waldenstrom's macroglobulinemia

growth factor

measurable disease

bone marrow biopsy

venetoclax

0 views
16 Feb, 2024
2 locations

Phase 1
For Seniors
For adults
Recruiting in 10s
Interventional Study
all
Family Medicine
Recruiting

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

The purpose of this study is to test the safety of 19(T2)28z1xx CAR T cells in people with relapsed/refractory B-cell cancers. The researchers will try to find the highest dose of 19(T2)28z1xx CAR T cells that causes few or mild side effects in participants. Once they find this dose, they …

direct bilirubin

monoclonal antibodies

tositumomab

burkitt's lymphoma

richter syndrome

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05 Aug, 2020