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Trial of Inhaled Anti-viral (SNG001) for SARS-CoV-2 (COVID-19) Infection

IFN- in produced in the lungs during viral lung infections. It has been shown that older people and people with some chronic diseases have an IFN- deficiency. Many viruses inhibit IFN- as part of their strategy to evade the immune system. Addition of IFN- in vitro protects lung cells from …

Using Telerehabilitation to Support Families of Children With Motor Difficulties Aged 3-8 Years Old

Background: Many children (about 1 child out of 20) have motor delays that are sometimes seen as "minor" and are not immediately explained by a specific diagnosis. These children are often underserved by existing health and rehabilitation services even though they are at risk of developing important negative outcomes in …

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-nave smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …

Home-based Aerobic Training Among Adolescents With Chronic Diseases During COVID-19 Pandemic

Data show that the coronavirus disease 2019 (COVID-19) symptoms can be severe in 4% and 3% of the adolescents aged 11-15 years and 16 years, respectively. In addition, the prevalence of chronic diseases among adolescents has increased in the last years. About 20% of the adolescents have some chronic disease, …

Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging

Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan. The anti-diabetic drug metformin is considered a likely pharmaceutical candidate to slow aging.

Antioxidant-rich Diet and Oxidative Stress in Healthy Preschoolers

Given that many diseases can start as early as childhood, eating patterns in childhood and preventing oxidative damage can have beneficial long-term health effects. Antioxidant-rich foods can slow down the progression of chronic diseases. In Slovenian kindergartens (and schools) children consume up to 70% of their daily energy and nutritional …

testslug trial title

Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; up to 40% of patients do not benefit sufficiently from existing antidepressant interventions including trials of medication and psychotherapy.

Effects of Age and Obesity on Brain Insulin Sensitivity

Recent evidence from clinical studies have shown that T2D almost doubles the risk for dementia. As the population gets older, age-related chronic diseases, as T2D, become more prevalent. Scientific evidence is emerging that there are several links between metabolic and neurocognitive functions.