Found 474 clinical trials
First-in-human Single Agent Study of SAR442085 in Relapsed or Refractory Multiple Myeloma
Primary Objectives: Dose Escalation Part A: To determine the maximum tolerated dose (MTD) of SAR442085 administered as a single agent in patients with relapsed or refractory multiple myeloma (RRMM), and determine the recommended Phase 2 dose (RP2D) for the subsequent Expansion Part B Dose Expansion Part B: To assess the …
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- 04 Dec, 2020
- 8 locations
Effect of Fibre Supplements on Gestational Diabetes (GG-GDM) : For Demo
The primary aim of this study is to evaluate the effect of a soluble fibre supplement in the development of gestational diabetes in women at high-risk. The secondary aim will to evaluate the effect of the soluble fibre supplement on glycaemic control in high-risk women who develop gestational diabetes in …
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- 07 Oct, 2022
- 3 locations
Comparison of Diuretic Effect With Furosemide Alone Versus the Combination of Furosemide and Albumin in Cirrhotic Patients
Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients demonstrate diuretic resistance, requiring higher doses of the diuretics to achieve adequate diuresis. The cause of this diuretic resistance is hypothesized to be secondary to hypoalbuminemia which has led some providers to …
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- 16 Feb, 2024
- 1 location
A Prospective Clinical Study of Transthoracic Single-hole Assisted Laparoscopic Radical Gastrectomy for Siewert AEG
Primary study endpoints: The incidences of early postoperative complications and mortality. The secondary study endpoints:(1) Surgery and oncology indicators ;(2) Early postoperative recovery information ;(3) 3-year disease-free survival and overall survival rate;(4) 5-year disease-free survival and overall survival.
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- 16 Feb, 2024
- 1 location
Nigella Sativa in COVID-19
The primary outcome will be the proportion of patients who clinically recovered on day 14. The secondary outcomes will be clinical parameters and routine laboratory tests. If encouraging outcomes occurred, NS supplementation may be recommended as an add-on to standard care protocol to enhance the recovery from COVID-19 disease in …
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- 01 Feb, 2023
- 1 location
Impact of Acetazolamide in Reducing Referred Postoperative Pain
Insufflation with CO2, however, has been linked to post-operative referred pain secondary to peritoneal acidosis.This acidosis is suspected to be due to the formation of carbonic acid from the CO2 insufflation.Peritoneal acidosis, and its associated post-operative referred pain, may not be adequately treated with the current standard pain control regimen.
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- 16 Feb, 2024
- 1 location
Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Primary objectives include comparing AOT efficacy between these groups and a control group. Secondary objectives focus on upper limb functionality, daily activities, balance, cognition, and gait.
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- 07 Jul, 2023
- 1 location
Radiomics Tool for Pulmonary Nodule Risk Stratification
., the biopsy was non-diagnostic), we will define pulmonary nodule resolution, shrinkage, or diameter stability at 12 months as a benign diagnosis. Secondary outcome variables will include measures of quality (timeliness), harms (adverse events), diagnostic yield, and healthcare costs.
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- 11 Jul, 2024
- 1 location
Effects of Age and Obesity on Brain Insulin Sensitivity
Additionally, structural changes and cognitive processes will be assessed as secondary variables.
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- 05 Aug, 2020
Integrative Study of Physiological Changes Induced by a 5-Day Dry Immersion on 20 Healthy Female Volunteers (DI5-Women)
The clinical (adverse effects, comfort of subjects) and operational aspects are also part of the secondary objectives of the study.
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- 16 Sep, 2021
- 1 location