Found 1831 clinical trials
Dose Escalation Study of PF-07209326 in Healthy Participants
This Phase 1 first-in-human single ascending dose and multiple dose study will be a randomized, double-blind, placebo-controlled investigation of the safety, tolerability, and pharmacokinetics of PF-07209326.
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- 16 Feb, 2024
- 1 location
Effects of Autogenic and Reciprocal Inhibition Techniques With Conventional Therapy in Mechanical Neck Pain
Group 1 will receive Autogenic Inhibition muscle energy technique (MET) with conventional therapy and Group 2 will receive Reciprocal inhibition MET with conventional therapy. A total of 12 sessions will be provided. Outcomes will be assessed at baseline, after 1st session, and at last session.
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- 16 Sep, 2021
- 1 location
v4.7 Sprint Demo Study - TrialX
We will compare primary and secondary outcomes in this model to those in the usual care model for adult diabetes management at MGH Diabetes Center. Those who agree to the research study will be asked to complete a series of three survey questionnaires over the timeframe of the study. The …
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- 14 Apr, 2022
- 6 locations
A Study to Evaluate the Safety and Tolerability of Single and Multiple Ascending Doses of HPN-01 in Healthy Subjects
This study is a randomized, double-blind, placebo-controlled first-in-human study in which the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered HPN-01 will be evaluated in healthy subjects
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- 05 Aug, 2020
Impact of Pomegranate Seed Oil on Postprandial Cardiovascular Disease Risk Markers
The anthropometric, blood pressure, and arterial stiffness, will be taken for each study visit. Blood samples will be collected for the measurement of fasting lipids, glucose, insulin, inflammatory markers, and whole blood culture.
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- 22 Sep, 2023
- 1 location
Investigating the Effect of Single-session Sauna Use on Body Temperature
The goal of this initial pilot project is to ascertain whether an infrared sauna, the Curvey Sauna Dome, which is readily accessible (i.e., can be purchased by consumers in the US) can be used to conduct WBH that achieves an internal body temperature of of 101.3 F in healthy volunteers.
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- 16 Feb, 2024
- 1 location
PHP and Immunotherapy in Metastasized UM
In this study a combination therapy with immunotherapy (ipilimumab with nivolumab) and chemotherapy (melphalan) will be assessed for the treatment of disseminated uveal melanoma. Melphalan will be administered selectively to the liver via percutaneous hepatic perfusion, limiting the systemic effect of chemotherapy.
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- 16 Feb, 2024
- 1 location
Naproxen Pharmacogenetic Study (Project 1 Aim 2)
This is a mechanism-based study in healthy adults to determine the effect of the CYP2C9 M1L gene polymorphism on the functional activity of the encoded CYP2C9 enzyme towards the probe substrate naproxen. CYP2C9 activity will be evaluated by measurement of O-desmethyl naproxen and unchanged naproxen in 24-hour urine following administration …
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- 16 Feb, 2024
- 1 location
Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors
Approximately 100 adult participants with locally advanced, recurrent, or metastatic solid tumors will be enrolled.
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- 16 Feb, 2024
- 2 locations
Safety Tolerability and Pharmacokinetic of Recombinant Anti-IL-5 Humanized Monoclonal Antibody Injection
There are 6 Groups as follows: 0.03mg/kg (S1), 0.2mg/kg (S2), 1.0mg/kg (S3), 3.0mg/kg (S4), 5.0mg/kg (S5) and 7.5mg/kg (S6); and 2 subjects were included in the S1 group (both received study drugs); 10 subjects were included in each of the S2 ~ S6 groups (of which 8 received study drugs …
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- 16 Feb, 2024
- 1 location