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Found 23 clinical trials
Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of CC-94676 in Subjects With Metastatic Castration-Resistant Prostate Cancer

This is a first in human study to assess the safety, tolerability, PK, PD and preliminary efficacy of CC-94676 in men with progressive metastatic castration-resistant prostate cancer.

abiraterone
androgen suppression
gonadotropin releasing hormone
metastatic castration-resistant prostate cancer
apalutamide
  • 0 views
  • 05 Aug, 2020
A Study of CC-98633 BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells in Subjects With Relapsed and/or Refractory Multiple Myeloma

The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at …

measurable disease
bcma
immunotherapeutic agent
pomalidomide
ixazomib
  • 0 views
  • 05 Aug, 2020
Adaptative MR-Guided Stereotactic Body Radiotherapy of Liver Tumors

Stereotactic radiotherapy is a recent technique proposed to hepatic metastases treatment from solid cancers and primary hepatic lesions (HCC or cholangiocarcinomas); it is possible to deliver high doses of radiation in the most conformational way possible in order to limit the irradiation of the non-tumor liver.

hepatitis
skin cancer
stereotactic radiation therapy
liver diseases
chelates
  • 0 views
  • 16 Feb, 2024
  • 1 location
Effect of Kangaroo Care on Test Weighing

The study will be conducted with the Crossover Randomized Controlled Method. The infants who have attained oral feeding in the neonatal intensive care unit will be divided into two groups via randomization in the computer environment. After the randomization, kangaroo care will be applied to the infants in Group 1 …

  • 0 views
  • 16 Feb, 2024
  • 1 location
Prospective Register on the Etiologies of Cardiogenic Shock and Their Prognosis at One Year.

This definition of the European Society of Cardiology (ESC) masks however the great variability of hemodynamic tables grouped under the term of CC and severity levels, also variable.However, it was suggested that the etiology of CC influenced both its hemodynamic profile and therefore its therapeutic management but also its prognosis …

pulmonary edema
hypoperfusion
confusion
hyperlactatemia
heart failure
  • 0 views
  • 16 Feb, 2024
  • 1 location
Saliva as Source of Detection for SARS-CoV-2

Eligibility NIH staff members age 18 and older who are taking part in NIH CC SARS-CoV-2 surveillance. Design The Occupational Medical Service (OMS) collects NP swabs as part of standard NIH staff screening.

nasal swab
nasopharyngeal swab
SARS
discomfort
acute respiratory syndrome (sars)
  • 0 views
  • 16 Feb, 2024
  • 1 location
Surveillance of Individuals Following SARS-CoV-2 Exposure

Background People who have had contact with a person with a known SARS-CoV-2 infection are being told to self-quarantine for 14 days. This is done to avoid potential virus spread. But the actual time it takes for a person to develop an infection after being exposed to the virus is …

acute respiratory syndrome (sars)
covid-19
SARS
  • 0 views
  • 05 Aug, 2020
Characterization of Novel Lipoprotein Properties Associated With an Increased Risk to Develop Atherosclerosis

Objectives of Medical Research: Separation of LDL and HDL from blood samples of patients with high LDL and / or low HDL who have developed atherosclerotic disease with similar patients who have no evidence of atherosclerosis. Lipidomics and proteomics will examine whether there is a difference in lipid and protein …

cardiovascular disease
atherosclerosis
  • 0 views
  • 05 Aug, 2020
Diagnosis Treatment Status and Prognosis of Cholangiocarcinoma in China: a Multicenter Two-way Non-intervention Study

This is a multicenter, two-way, non-intervention study. the main purpose: Understand the current status of diagnosis and treatment of cholangiocarcinoma patients in China and observe the effect of different treatment options on patient recurrence and long-term survival Secondary purpose: Exploring the actual clinical treatment situation and its compliance with the …

cancer
cholangiocarcinoma
  • 0 views
  • 16 Feb, 2024
  • 1 location
PROtocol of Metabolic and Cryptogenic livEr Disease regisTry for intEgration of Omic Studies

The main aim of the study is to set up an observational cohort with NAFLD (Non-alcoholic fatty liver disease) at different stage of disease (from simple steatosis to cirrhosis and/or HCC-Hepatocellular carcinoma) and for comparative purpose a cohort of subjects with diabetes and/or obesity and/or other risk factors (i.e. psoriasis, …

inflammatory bowel disease
psoriasis
cirrhosis
carcinoma
hepatitis c
  • 0 views
  • 16 Feb, 2024
  • 1 location