Found 233 clinical trials
Brief Title: Study of BGB-10188 as Monotherapy and in Combination With Zanubrutinib and Tislelizumab
The purpose of this study is to determine the maximum tolerated dose (MTD), recommended Phase 2 dose(RP2D),safety & tolerability of BGB-10188: as monotherapy in participants with mature B-cell malignancies; oin combination with zanubrutinib in participants with relapse/refractory follicular lymphoma (R/R FL), mantle cell lymphoma (MCL) or diffuse large B-cell lymphoma …
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- 16 Feb, 2024
- 4 locations
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
They will be videotaped while they speak and read a paragraph.Blood tests. This might include genetic testing.Lung and breathing testsMRI. They will lie on a table that slides into a cylinder that takes pictures of the body. Some participants will get a dye through IV.
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- 19 Feb, 2025
A Study of SGN-B6A in Advanced Solid Tumors
This trial will look at a drug called SGN-B6A to find out whether it is safe for people who have solid tumors. It will study SGN-B6A to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether …
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- 05 Aug, 2020
A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis (BARRIER)
The goal of this study is to determine if viral infection with the common cold leads to an exacerbation in participants with bronchiectasis. We will compare the participants with bronchiectasis to a group of healthy participants. The main questions it aims to answer are:Does viral infection with the common cold …
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- 23 Apr, 2025
- 1 location
To Assess the Efficiency and Satisfaction of Pharmacist Giving Patient-centred Advice on Telephone Consultation in TB Patients: Experience of the COVID-19 Pandemic
The COVID-19 pandemic might be an opportunity to review and refine our practices in anti TB treatment. For the follow-up of selected patients, telephone consultations may be efficient and cost-effective. The aim of the study is to assess the efficiency and the satisfaction with telephone consultation for the pharmacist and …
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- 05 Aug, 2020
Long Term Functional Outcomes of COVID-19 Patients Treated by Rehabilitation Services viaTelehealth
This study seeks to assess the impact of physical and pulmonary rehabilitation on patients who have been diagnosed with COVID-19 in the short and long term in hopes of establishing a best practices protocol for treatment of future patients with this disease.
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- 16 Feb, 2024
- 1 location
Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death
Normothermic regional perfusion (NRP) utilizes Extracorporeal Membrane Oxygenation (ECMO) or cardiopulmonary bypass to reperfuse the heart and other organs in situ after isolation and ligation of the cerebral vessels. In situ resuscitation of the heart has the added advantage of allowing full hemodynamic and echocardiographic assessment of the donor heart …
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- 16 Feb, 2024
- 1 location
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis
This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work in treating patients with pneumonitis that does not respond to steroid treatment. Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow …
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- 16 Feb, 2024
- 1 location
External Dead Space in Ventilated COVID-19 Patients
The objective is to investigate the efficacy of volumetric capnography to detect changes in dead space, CO2 elimination and shape factor parameters before and after disconnection of external dead space in ventilated COVID-19 patients.
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- 05 Aug, 2020
Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI
Rationale: Transcatheter aortic valve implantation (TAVI) has become the standard therapy for elderly patients with high surgical risks. Paravalvular leakage after TAVI is relatively common and there is conflicting evidence regarding the clinical impact of mild paravalvular leakage in self-expanding devices. Prospective data for self-expanding devices are required to compare …
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- 16 Feb, 2024
- 1 location