Found 1435 clinical trials
Safety Pharmacokinetics and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation
Phase 2: To evaluate the efficacy of isatuximab in desensitization of patients awaiting kidney transplantation. Secondary Objectives: Phase 2: To characterize the safety profile of isatuximab in kidney transplant candidates. To characterize the pharmacokinetic (PK) profile of isatuximab in kidney transplant candidates.
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- 16 Feb, 2024
- 2 locations
A Study to Evaluate the Pharmacokinetics Safety and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants
This is a Phase 1, randomized, single-dose, double-blinded, 4-period, crossover study to evaluate the pharmacokinetics, safety, and tolerability of mitapivat in healthy adult participants under fasted and fed (high-fat meal) conditions. Secondary objectives include evaluating the effect of mitapivat on electrocardiogram (ECG) parameters, including concentration-QT interval corrected for heart rate …
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- 16 Feb, 2024
- 1 location
v4.7 Sprint Demo Study - TrialX
This study is a quasi-randomized mixed methods evaluation of the implementation of an innovative collaborative care model to assess whether it is feasible and improves indicators of diabetes and mental health, while exploring themes that will inform redesign of the care model to improve healthcare delivery to young adults with …
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- 14 Apr, 2022
- 6 locations
Reduced Occupational Sitting in Type 2 Diabetes Using mHealth (Mobile Health)
It is hypothesized that the intervention will lead to (1) Activity changes - reduced sitting time and/or increased number of steps (primary outcome measures) and (2) Health effects - lower fatigue, improved health-related quality of life, reduced cardiometabolic risk, less sick leave, less medication, less musculoskeletal problems (secondary outcome measures)
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- 16 Feb, 2024
- 1 location
A Phase 1b Trial to Evaluate Safety and Effect of SAR443122 on Immune System in Severe COVID-19
Primary Objective: To evaluate the effect of SAR443122 relative to the control arm on the hyperinflammatory state as measured by C-reactive protein (CRP) levels in adult patients hospitalized with severe COVID-19 Secondary Objectives: To evaluate the time to onset of effect of SAR443122 relative to the control arm on the …
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- 05 Aug, 2020
CAD/CAM Fixed Retainers vs. Conventional Multistranded Fixed Retainers in Orthodontic Patients. Comparison of Stability Retainer Failure Rate Adverse Effects Cost-effectiveness and Patient Satisfaction. A Randomized Controlled Clinical Trial
multistranded wire, in terms of stability (primary outcome), failure rate, adverse effects, cost-effectiveness, and patient satisfaction (secondary outcomes), substantial up to 5 years after retainer placement. Hypotheses Compared to traditional multistranded FRs, CAD/CAM FRs have: Better long term stability, Similar failure rate, Fewer adverse effects, Similar cost-effectiveness and patient satisfaction.
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- 05 Aug, 2020
A Study of TTYP01 in Healthy Adult Subjects
This is integrated Phase 1, Single centre, Randomized study will be conducted in 3 parts, each with a specific primary objective: Part A: To characterise the safety and tolerability of TTYP01 in healthy adult subjects; Part B: To evaluate the bioavailability of TTYP01 tablets in healthy adult subjects; Part C: …
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- 05 Aug, 2020
New Information and Communication Technologies (ICT s) in Basic Life Support Training for Non-medical Students: Educational Trial
The clinical trial will compare that two educational strategies, evaluating as primary aid, which approach has higher knowledge retention of life support chain at 6 months in students after the workshop. As secondary objectives, the investigators would evaluate the efficient in terms of response times, costs and student satisfaction. This …
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- 16 Feb, 2024
- 1 location
Role of Inflammasomes in COVID-19 Disease
As of March 25, 2020, 414,179 cases and 18,440 deaths secondary to Coronavirus 2019 disease (COVID-19) have been reported worldwide. The unfavorable course of the patients is characterized on the immunological level by an intense pro-inflammatory response which can go as far as a cytokinic storm.
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- 16 Feb, 2024
- 2 locations
PQ Test Trial ( Do not edit)
George's Respiratory Questionnaire (SGRQ) in former smokers with moderate-to-severe COPDEvaluate the safety and tolerability of itepekimab in former smokers with moderate-to-severe COPDEvaluate the pharmacokinetic (PK) profile of itepekimab in former smokers with moderate-to-severe COPDEvaluate immunogenicity to itepekimab in former smokers with moderate-to-severe COPDSecondary population (current smokers cohort)Estimate the efficacy of …
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- 01 Apr, 2024
- 4 locations