Found 1056 clinical trials
COVID-19 Seroprevalence Study in French Guiana
Serological surveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies in the population to assess the extent of the infection and the COVID-19 immunity of the population in French Guiana.
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- 16 Feb, 2024
- 5 locations
Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"
The COVID-19 pandemic has been characterized by high morbidity and mortality, especially in certain subgroups of patients. To date, no treatment has been shown to be effective in controlling this disease in hospitalized patients with moderate and / or severe cases of this disease. Hydroxychloroquine and lopinavir / ritonavir have …
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- 16 Feb, 2024
- 4 locations
Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
To investigators' knowledge, this is the first study investigating effects of HFNC on sputum clearance in COPD patients. The purpose of the study is to determine the effects of HFNC on sputum clearance in acute exacerbation of COPD.
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- 16 Feb, 2024
- 1 location
A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis (BARRIER)
The goal of this study is to determine if viral infection with the common cold leads to an exacerbation in participants with bronchiectasis. We will compare the participants with bronchiectasis to a group of healthy participants.
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- 23 Apr, 2025
- 1 location
Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis
The aim of this study is to find out if endoscopic sinus surgery improves the quality of life in patients suffering from recurrent acute rhinosinusitis. Our main outcome is the difference between the average change in disease-specific SNOT-22 quality of life questionnaire scores (from baseline to 5-6 months follow-up) between …
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- 16 Feb, 2024
- 1 location
Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia
To assess the clinical efficacy of ANG-3777 relative to the standard of care in reducing the severity and progression of pulmonary and renal dysfunction and mortality in adult patients hospitalized with COVID-19 pneumonia
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- 05 Aug, 2020
Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia
Vitamin C is significant to human body and plays a role in reducing inflammatory response and preventing common cold. In addtion, a few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections.
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- 16 Feb, 2024
- 1 location
Selfcare MAnagement InteRvenTion in COPD (SMART COPD)
To evaluate whether a digital support and communication platform for COPD patients after 6 months provides: Decreased breathlessness on the basis of modified medical research council dyspnea scale [mMRC] Improved health status and symptom relief based on COPD assessment scale [CAT] Improved quality of life based on EQ-5D Reduction in …
- 0 views
- 05 Aug, 2020
A Study to Evaluate Efficacy and Safety of PTC299 in Hospitalized Participants With Coronavirus (COVID-19)
This is a randomized, double-blind, placebo-controlled, multicenter, 28-day study of adult participants hospitalized with COVID-19, with a safety follow-up telephone call at Day 60.
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- 16 Feb, 2024
- 5 locations
Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflation
The purpose of this prospective, Phase 2, multicenter, blinded, randomized placebo controlled study is to demonstrate that early treatment with mavrilimumab prevents progression of respiratory failure in patients with severe COVID-19 pneumonia and clinical and biological features of hyper-inflammation.
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- 01 Feb, 2023
- 1 location