Found 24 clinical trials
Effects of Almond Consumption on the Human Gastrointestinal Microbiota and Metabolic Health
The proposed work will investigate the effect of almond consumption as a snack on human gastrointestinal microbiota and on metabolic health.
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- 16 Feb, 2024
- 1 location
Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD
Response to steroids is observed only in about 10% of patients. The most promising approaches are JAK inhibition and fecal microbiota transplantation. In this pilot study we evaluate this combination treatment in the first line.
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- 16 Feb, 2024
- 1 location
A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function
This exploratory, open-label clinical study aims to explore the physiologic effects of KB109, a novel glycan, on adult patients with COVID-19 illness on gut microbiota structure and function in the outpatient setting.
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- 16 Feb, 2024
- 1 location
Utilization of Microbiome as Biomarkers and Therapeutics in Immuno-Oncology
This research consists of two parts: part 1: development of microbiome biomarkers for immuno-oncology part 2: proof-of-concept trial on the fecal microbiota transplantation in patients who are being treated with immunotherapy for advanced solid tumor
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- 16 Feb, 2024
- 1 location
Fiber Metabolism in Chronic Obstructive Pulmonary Disease
The impact of fiber intake on short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare changes in SCFA metabolism after inulin vs. placebo intake in COPD patients to healthy matched controls. This protocol is an extension …
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- 16 Feb, 2024
- 1 location
Dynamics of the Urinary Bacterial Microbiota (DAIQUIRI)
It has thus been suggested that, following a disruption in the homeostasis of the urinary microbiota (urinary dysbiosis), certain bacteria considered commensals of the urinary tract can become pathogenic and lead to UTIs (Gerges-Knafl et al., 2020).
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- 16 Jun, 2025
Effect of MEDiterranean Diet on the microBIOME of Individuals With Type 2 Diabetes
Dysbiosis of gut microbiota is associated with the pathophysiology of type 2 diabetes. Mediterranean diet has been indicated as a dietary pattern that promote the integrity of gut barrier and that has positive impact in the metabolic control of subjects with type 2 diabetes.
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- 16 Feb, 2024
- 1 location
Effect of Ketone Esters in Parkinson's Disease
Ketones esters have shown to improve mitochondrial function and are currently use to enhanced functional performance. As Mitochondrial dysfunction is one of the proposed mechanism of neuronal injury in Parkinson's disease, the study aims to assess the tolerability,side effects and effect of oral ketone esters in Patients with Parkinson's disease.
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- 05 Aug, 2020
A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis (BARRIER)
The goal of this study is to determine if viral infection with the common cold leads to an exacerbation in participants with bronchiectasis. We will compare the participants with bronchiectasis to a group of healthy participants. The main questions it aims to answer are:Does viral infection with the common cold …
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- 23 Apr, 2025
- 1 location
Epidemiologic Clinical Molecular Characteristics of Hospital Employees With or Without Covid-19 Infection
The study cohort will be enrolled among all Humanitas group employees (including ICH, Humanitas University and Gavazzeni), and two validation cohorts. Participants will be asked consent for the research use of blood, pharyngeal swab, and for those hospitalized for COVID-19, also for the bronchoalveolar lavage and fecal samples. Biological samples …
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- 16 Feb, 2024
- 1 location