Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI

  • STATUS
    Recruiting
  • End date
    May 1, 2026
  • participants needed
    20
  • sponsor
    Jonsson Comprehensive Cancer Center
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Updated on 16 February 2024
See if I qualify
cancer
metastasis
MRI
brain metastases
brain tumor
brain metastasis
neoplasm
MET
magnetic resonance imaging

Summary

This trial looks to study the safety and feasibility of using oxygen-enhanced molecular MRI to understand how cancer cells use oxygen differently than normal cells. Cancer cells tend to utilize (or not utilize) oxygen differently than normal cells. By using the oxygen-enhanced molecular MRI, researchers will be able to create spatial "maps" depicting areas of abnormal oxygen utilization unique to cancer. This type of information may be useful for diagnosing new cancers, understanding various "subtypes" of cancer that might utilize oxygen differently, or this information may be useful for evaluating new drugs that impact cancer metabolism.

Description

PRIMARY OBJECTIVES:

I. Determine the safety, feasibility, and sensitivity of oxygen-enhanced molecular magnetic resonance imaging (MRI) in healthy volunteers.

II. Measure oxygen-enhanced molecular MRI characteristics in human brain tumors.

OUTLINE

Participants undergo arterial spin labeling (ASL) MRI scan and amine chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging using amine proton CEST echo spin-and-gradient echo (SAGE) EPI (CEST-SAGE-EPI) while breathing normal room air (21% oxygen). Patients then undergo another ASL MRI and CEST-SAGE-EPI while breathing medical grade air (100% oxygen). Total ASL MRI and CEST-SAGE-EPI imaging scan time is 60 minutes.

Details
Condition Malignant neoplasm of brain
Age 100years or below
Treatment Arterial Spin Labeling Magnetic Resonance Imaging, pH-Weighted amine CEST, Oxygen-weighted SAGE-EPI
Clinical Study IdentifierNCT04460495
SponsorJonsson Comprehensive Cancer Center
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Healthy volunteers will include persons who at the time of scans do not present with known neurological conditions that might impact tissue imaging results
Patient participants should have suspected or pathology-confirmed diagnosis of a brain tumor (any histological subtype including brain metastases)
All participants must be able to obtain an MRI scan and must be able to safely breathe high concentrations of oxygen

Exclusion Criteria

Participants with contraindications to MRI including metal implants
Participants who are deemed not able to or not safe to breath high concentrations of oxygen
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