Oral Oxytocin's Effects on Attention Control

  • STATUS
    Recruiting
  • participants needed
    80
  • sponsor
    University of Electronic Science and Technology of China
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Updated on 16 February 2024
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Summary

The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate attention control using a social-emotional saccade/antisaccade eye-tracking paradigm.

Description

Numerous studies have reported the effect of intranasally administered oxytocin on attentional processing including stimulus-driven bottom-up processing and top-down goal-directed inhibitory control. However, it is unclear whether the functional effects are mediated by the peptide directly entering the brain or indirectly via raising peripheral concentrations. One possible method of producing a similar pattern of increased peripheral oxytocin concentrations but without the possibility of direct entry into the brain would be to administer the peptide lingually. In the present double-blind, between-subject, placebo-controlled study, 80 healthy male subjects will be recruited and receive either oxytocin (24IU) or placebo control administered orally (lingual). 45 minutes after treatment subjects are required to complete a social-emotional saccade/antisaccade eye-tracking paradigm. This paradigm uses social (happy, sad, angry, fear, and neutral faces) as well as non-social (oval shapes) stimuli to explore social- and emotion-specific effects of orally administered oxytocin.

Details
Condition Healthy
Age 18years - 30years
Treatment Oral Placebo, Oral Oxytocin
Clinical Study IdentifierNCT04493515
SponsorUniversity of Electronic Science and Technology of China
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Male, healthy participants
Non smokers

Exclusion Criteria

Previous or current medical, psychiatric, neurological disorder
Regular medication
Use of any psychoactive substances in the 24 hours before experiment
Contra-indications for oxytocin
Contra-indications for eye-tracking data acquisition
Clear my responses
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