Effects of Baclofen on Presynaptic Inhibition in Humans

  • STATUS
    Recruiting
  • participants needed
    46
  • sponsor
    University of Alberta
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Updated on 16 February 2024
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spasticity
baclofen
gaba-b receptor agonist

Summary

This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants. Participants will come in for two visits, receiving baclofen (a GABA-B receptor agonist) on one visit and a placebo during the other. Electro-physiological measures will be use during both visit to asses presynaptic inhibition.

Description

The ability to execute purposeful movements relies on sensory information coming from the body. This sensory information tells us where are limbs are in relation to the rest of our body (posture sense), how fast they are moving (kinesthetic sense), how forcefully we are making a contraction (muscular sense) and if we are being contacted by external objects, changes in temperature, pain, etc (somatic sense). Without these senses, we could not make well controlled movements or navigate in our environment safely. Because of the importance of these sensory inputs, the nervous system has designed a highly regulated system to control the amount and quality of sensory inflow entering into both the spinal cord and brain. We wish to re-investigate how sensory pathways from our body controls the inflow of sensory inputs in adults with and without neurological injury. Specifically, we want to test if the long-lasting suppression of sensory inflow by other sensory nerves is regulated by GABA-B receptors. We will test this by giving participants the GABA-B receptor agonist baclofen. Nerve stimulation and muscle responses will be used to understand how sensory transmission is being controlled in the spinal cord and the GABA-B receptors involvement. Results from these studies will provide important fundamental information about how normal sensory inflow is controlled so that we can better understand how it may be altered after injury to the brain and spinal cord. This information will open new avenues of study into the treatment of sensory-related dysfunction such as spasticity and motor incoordination that occurs after central nervous system injury or disease.

Details
Condition Spinal Cord Injury, Myelopathy, spinal cord disorders, Trauma, wounds, Spasticity, wounds, spinal cord disorders
Age 18years - 65years
Treatment Baclofen
Clinical Study IdentifierNCT04471714
SponsorUniversity of Alberta
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Healthy adults between the ages of 18 and 65 years
General good health

Exclusion Criteria

Contraindications to baclofen such as a known hypersensitivity to baclofen, renal impairment, stroke, epilepsy, pregnancy and lactation
Injury to peripheral nerves or muscles. Injury to nerves or muscles will confound the interpretation of the spinal reflex data
Participants with spinal cord injury already taking oral baclofen to manage spasticity
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