SubsTRate OxidatioN in Girls

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Pennington Biomedical Research Center
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Updated on 16 February 2024
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Summary

This study will examine race differences in total energy expenditure and respiratory quotient (RQ) during and after exercise, compared to a sedentary control condition, in adolescent girls who are classified as overweight. In addition, subjective appetite will be measured throughout the assessment periods.

Description

Aim 1: Measure 24-hour energy expenditure and its components (resting, activity, and sleep energy expenditure) and compare differences between African-American and White girls.

Hypothesis: Total, resting, and sleep energy expenditure will be lower in African-American relative to White girls. Activity energy expenditure will be equivalent per the study design.

Aim 2: Measure and compare substrate oxidation and associations with appetite (i.e., hunger, desire to eat) in the context of energy balance between African-American and White girls.

Hypothesis: African-American girls will have a higher RQ at rest, during exercise, and following exercise, and RQ will be positively associated with subjective appetite ratings.

Details
Condition Overweight Adolescents
Age 13years - 17years
Treatment Acute exercise
Clinical Study IdentifierNCT04483921
SponsorPennington Biomedical Research Center
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Female
Age 13-17 years, inclusive
Achieved menarche based on parent- and/or self-report
Overweight based on BMI percentile for age and sex ( 85th and < 95th)
Self-identification as non-Hispanic White or African-American
Willing to maintain current physical activity, sleep schedule, and dietary habits during the study
Willing to comply with study procedures

Exclusion Criteria

Contraindications to exercise testing as defined by the American College of Sports Medicine (i.e., medical history of cardiovascular, pulmonary, or physical conditions that affect the ability to exercise)
Food allergies
Dietary restrictions
Unwilling to consume study foods
History of polycystic ovary syndrome (PCOS)
Current amenorrhea or other menstrual cycle irregularities
Pregnant or currently breastfeeding
Current anemia
Use of medications affecting metabolism or sleep
Inability to properly or safely complete the study procedures per the investigators' discretion
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