Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease

  • STATUS
    Recruiting
  • participants needed
    10
  • sponsor
    University Hospital, Basel, Switzerland
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Updated on 16 February 2024
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MRI
mri study
mitral valve repair
annuloplasty

Summary

Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.

Details
Condition VALVULAR HEART DISEASE, Mitral Regurgitation, Barlow Disease (BD)
Age 18years - 100years
Treatment Magnetic Resonance Imaging (MRI)
Clinical Study IdentifierNCT04418960
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

identified Barlow disease suffering from significant mitral insufficiency with indication to surgery

Exclusion Criteria

Active endocarditis or any other etiology of mitral insufficiency else than Barlow disease
Inability to perform a cardiac MRI (e.g., metallic implants, claustrophobia)
Pregnancy
Inability to give consent
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