Study of Tapering and Discontinuing Biological DMARDs in Rheumatoid Arthritis Patients

  • STATUS
    Recruiting
  • participants needed
    400
  • sponsor
    National Taiwan University Hospital
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Updated on 16 February 2024
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DMARD
arthritis
tumor necrosis factor alpha
disease modifying antirheumatic drugs

Summary

This study aims to analyses time to disease relapse of RA patients if TNF- inhibitors are being tapered, the predictive factors that are associated with successful taper of TNFinhibitors. Also, investigate the effects associated with dose tapering of TNF- inhibitors.

Details
Condition Rheumatoid Arthritis, Rheumatoid Arthritis
Age 20years - 90years
Clinical Study IdentifierNCT04472390
SponsorNational Taiwan University Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Diagnosed of RA based on the 1987 American College of Rheumatology (ACR)
criteria and/or 2010 ACR/EULAR classification criteria of RA depending on the
time of diagnosis Age 20 years old TNF- inhibitors was prescribed for RA
patients refractory to csDMARDs (defined as csDMARD therapy for over 6 months)
during 2003/5/2 - 2017/4/30 Dose reduction or discontinuation use of TNF-
inhibitors (2011/1/1-2019/4/30)

Exclusion Criteria

TNF- inhibitors were discontinued or tapered due to adverse events such as
infection, liver transaminase elevation, malignancy and neutropenia
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