The Influence of Coronary Chronic Total Occlusion on Myocardial Perfusion on Computed Tomography

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Institute of Cardiology, Warsaw, Poland
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Updated on 16 February 2024
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ct scan
computed tomography
MRI
coronary artery disease
ejection fraction
angiography
ischemia
angina pectoris
coronary disease
perfusion imaging
medical therapy
chronic total occlusion
computed tomography perfusion imaging

Summary

The COPACABANA study is designed as a single-centre, open, prospective trial aimed to assess the influence of coronary chronic total occlusion (CTO) on downstream myocardial ischemia via the novel computed tomography perfusion (CTP) imaging technique. To this end, consecutive patients with CTO of a major coronary artery scheduled to undergo percutaneous recanalization of occluded coronary artery based on clinical grounds, will undergo stress CTP using state-of-the-art dual-energy CT scanner at 2 time points (before and 3 months after successful restoration of flow in the CTO vessel).

Details
Condition Coronary Artery Disease, Coronary Artery Disease, Myocardial Perfusion Imaging, Vascular Diseases, Vascular Diseases, Heart disease, Heart disease, Coronary Occlusion, Ischemic Heart Disease, Percutaneous Coronary Intervention
Age 18years - 100years
Treatment computed tomography perfusion imaging
Clinical Study IdentifierNCT04465526
SponsorInstitute of Cardiology, Warsaw, Poland
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

delivery of an informed consent and compliance with study protocol
persistent angina pectoris (CCS class 2) refractory to optimal medical therapy
CTO of a major coronary artery (left anterior descending artery, right coronary artery, left circumflex artery) of at least 2.5 mm vessel diameter confirmed by invasive angiography
preserved left ventricular ejection fraction (>50%) on echocardiography or cardiac magnetic resonance with preserved contractility in the CTO territory (normokinesia and/or hypokinesia)

Exclusion Criteria

unstable angina and/or myocardial infarction
prior myocardial infarction within 4 weeks before study enrolment
occurrence of myocardial infarction and/or unplanned revascularization between the index procedure and post-procedural CTP study
impaired renal function (eGFR 45 ml/min/m2)
contraindications to antiplatelet therapy and/or heparin
other contraindications to CTP (pregnancy, allergy to contrast media or pharmacologic stress agents, tachyarrhythmia, claustrophobia)
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ct scan
computed tomography
MRI
coronary artery disease
ejection fraction
angiography
ischemia
angina pectoris
coronary disease
perfusion imaging
medical therapy
chronic total occlusion
computed tomography perfusion imaging

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