Shear Wave Elastography of Rectal Adenomas and Cancer

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Vejle Hospital
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Updated on 16 February 2024
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cancer
stiffness
endoscopy
elastography
adenoma
shear wave elastography
endorectal ultrasonography

Summary

The diagnosis of rectal lesions is a challenging task, and the accuracy of the primary staging is important preoperatively. A relatively novel technology makes it possible to measure the tissue stiffness during endorectal ultrasonography.

The purpose of this study is to evaluate the diagnostic value of Shear Wave Elastography (SWE). The hypothesis is that the tissue stiffness is higher in malignant tissue than in benign lesions.

Description

This study will include patients with an endoscopy verified rectal lesion referred to the radiology department for pretreatment evaluation.

During the investigation, patients will undergo magnetic resonance imaging (MRI) and endorectal ultrasonography (ERUS). During the ERUS, the tissue stiffness of the lesion and visible lymph nodes will be measured using the SWE technology.

Hypotheses
  1. Tumour stiffness measurement by SWE gives a statistically significantly higher value in malignant processes than in benign rectal tumors.
  2. Tissue stiffness measurement with SWE gives a statistically significantly higher value in lymph node metastases than in reactive enlarged lymph nodes.
  3. There is a statistically significant correlation between SWE and MRI apparent diffusion coefficient (ADC)

Histopathology report of surgical specimen will serve as endpoint.

Details
Condition Colorectal Cancer, Colorectal Cancer, Rectal Cancer, Rectal Cancer, Magnetic Resonance Elastography
Age 100years or below
Treatment Shear wave elastography
Clinical Study IdentifierNCT04409990
SponsorVejle Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Adults above 18 years of age
Rectal lesions discovered during endoscopy
Lesions located no more than 15 cm above the anal verge

Exclusion Criteria

Non-eligibility for MRI (e.g. claustrophobia, implants)
Preoperative radiotherapy and/or chemotherapy
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