Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    Minia University
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Updated on 16 February 2024
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progesterone
ischemia
traumatic brain injury
transcranial doppler
progesterone therapy
progestin therapy

Summary

Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .

Description

Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices

Details
Condition Brain Injury, Brain Injury, Brain Injuries, Traumatic
Age 20years - 65years
Treatment Progesterone
Clinical Study IdentifierNCT04426487
SponsorMinia University
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Traumatic subarachinoid hemorrhage

Exclusion Criteria

History of malignency
History of cerebrovasculer stroke
Morbid obese
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