Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19

  • STATUS
    Recruiting
  • participants needed
    106
  • sponsor
    Grupo de Investigación Clínica en Oncología Radioterapia
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Updated on 16 February 2024
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pneumonia
covid-19
neutropenia
leukopenia
respiratory complications

Summary

Low radiation doses produce anti-inflammatory effects, which may be useful in the treatment of respiratory complications of COVID-19. This type of treatment is non-invasive and therefore, a priori, it can be used in all types of patients.

Main objective: To evaluate the efficacy of low-dose lung irradiation as an adjunctive treatment in interstitial pneumonia in patients with COVID-19 by improving the PAFI O2 by 20% measured 48h after treatment with respect to the pre baseline measurement. -irradiation.

Description

Study design: This is a prospective multicenter study in 2 phases:

  1. Exploratory phase. It will include 10 patients, to assess the feasibility and efficacy of low-dose lung irradiation. If a minimum efficiency of 30% is not achieved, the study will not be continued.
  2. Comparative phase in two groups, a control group, which will only receive pharmacological treatment, and an experimental one. It will include 96 patients, the allocation will be 1: 2, that is, 32 in the control arm and 64 in the experimental arm, which will receive low-dose lung irradiation.

Details
Condition Viral pneumonia
Age 18years - 99years
Treatment Azithromycin, Low Molecular Weight Heparin, Hydroxychloroquine Sulfate, Low-dose radiotherapy, Ritonavir/lopinavir, Tocilizumab Injection [Actemra], Corticosteroid, Oxygen supply
Clinical Study IdentifierNCT04380818
SponsorGrupo de Investigación Clínica en Oncología Radioterapia
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Leukopenia <1000
Pregnancy
Not understanding or refusing the purpose of the study

Exclusion Criteria

Age <18 years
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