Treatment of Patients With COVID-19 With Convalescent Plasma

  • STATUS
    Recruiting
  • participants needed
    120
  • sponsor
    University of Sao Paulo General Hospital
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Updated on 16 February 2024
See if I qualify
blood transfusion
pao2
FIO2
pneumonia
respiratory distress
intubation
oximetry
covid-19
fraction of inspired oxygen (fio2)

Summary

The COVID-19 pandemic has been spreading continuously, and in Brazil, until May 31, 2020, there have been more than 450.000 cases with more than 28.000 deaths, with daily increases. The present study proposes to evaluate the efficacy and safety of convalescent plasma in treatment of severe cases of COVID-19 in a multicenter, randomized, open-label and controlled study

Description

Eligible patients will be randomized 1:1:1 into 3 treatment groups: A- standard (control); Bstandard and convalescent plasma in a volume of 200ml (150-300ml); C- standard and convalescent plasma in a volume of 400ml (300-600ml). The Bayesian multi-arm and multi-stage model will be used, which will allow an interim analysis after the inclusion of 30 patients, with repeated interim analyses for every 30 additional patients. With this, we expect to define not only the efficacy of convalescent plasma, but also the volume of plasma needed if efficacy is proven. The study will be interrupted if the efficacy of the convalescent plasma group is proven, so that all severely ill patients as defined in the study can receive the convalescent plasma treatment. The same will occur if there is no difference in primary outcome with the use of convalescent plasma or serious adverse effects.

Details
Condition Covid 19
Age 18years - 100years
Treatment Convalescent plasma
Clinical Study IdentifierNCT04415086
SponsorUniversity of Sao Paulo General Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age = or > than 18 years
Laboratory-proven COVID-19 infection by RT-PCR in any clinical sample . Time since symptom onset less than 10 days at the time of screening; - . Presence of COVID-19 pneumonia, with a typical, indeterminate or atypical compatible image in a chest tomography exam (see definition below) -
Presence of one of the following criteria
Need for> 3L of O2 in the catheter / mask or> 25% in the Venturi mask to maintain O2 saturation> 92% B presence of respiratory distress syndrome with PaO2 / FiO2 <300mmHg If intubated, within 48 hours of orotracheal intubation
Absence of a history of serious adverse reactions to transfusion, for example, anaphylaxis; - .Participation approval by the research clinician

Exclusion Criteria

Already enrolled in another clinical trial evaluating antiviral or immunobiological therapy for the treatment of COVID-19
IgA deficiency
Presence of a clinical condition that does not allow infusion of 400 ml of volume at clinical discretion
Pregnancy or breastfeeding
Receipt of immunoglobulin in the last 30 days
Presence of significant risk of death within the next 48 hours at clinical discretion
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