Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Chinese Medical Association
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Updated on 16 February 2024
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aortic dissection

Summary

Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Details
Condition Family, Aneurysm, Aneurysm, Aortic Dissection, Familial, With or Without Aortic Aneurysm
Age 100years or below
Treatment movement
Clinical Study IdentifierNCT04439565
SponsorChinese Medical Association
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included

Exclusion Criteria

Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms
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