Role of Sympathetic Activation in Ischemia Reperfusion Injury

  • STATUS
    Recruiting
  • participants needed
    50
  • sponsor
    Royal Perth Hospital
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Updated on 16 February 2024
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Summary

This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote ischemic preconditioning. In addition it will assess whether pharmacologic inhibition of the sympathetic nervous system can ameliorate ischemia reperfusion injury induced endothelial dysfunction.

Description

This is a randomized single blind study where subjects will be allocated to undergo one of the 4 protocols. Participants will be given placebo or 0.2mg of Moxonidine to take orally 20 minutes prior to the first endothelial function measurement.

This medication acts by reducing the activity of nerves believed to be involved in the conditioning process. The placebo pill, designed to have no effect, will be used as a comparison. Comprehensive tests will occur which include Microneurography, Endothelial function ,Blood Sampling, Temporary block of arm blood flow and Remote conditioning

Details
Condition Central Sympathetic Nervous System
Age 18years - 75years
Treatment Placebo, Moxonidine 0.2 MG
Clinical Study IdentifierNCT04479813
SponsorRoyal Perth Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

healthy males, not on any medication, free of any history of metabolic, cardiovascular or cerebrovascular disease

Exclusion Criteria

smoker
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