Guided Tissue Regeneration in Healing of Through and Through Periapical Lesion

  • STATUS
    Recruiting
  • participants needed
    32
  • sponsor
    Postgraduate Institute of Dental Sciences Rohtak
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Updated on 16 February 2024
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Summary

Aim of this study is to evaluate the effect of i-PRF in the healing of through and through periapical lesion after periradicular surgery

Description

Detailed patient examination will be carried out and those satisfying inclusion criteria will be enrolled in the study. Written informed consent will be obtained and patients will be randomly allocated to two groups. Entire surgical procedure will be carried out by single operator. After complete elevation of the flap, debridement (periradicular curettage -enucleation) of the bony lesion will be performed. 3 mm root-tip resection will be performed and root end cavity will be prepared using an ultrasonic diamond-coated retrotip. Root end filling will be done with mineral trioxide aggregate (MTA). In test group The i-PRF will be produced and incorporated with collagen will be used to fill into the defect. In the control group, no guided tissue regeneration technique will be used. Flap will be re-positioned and sutured using nonabsorbable 4-0 silk sutures.Sutures will be removed 4-7 days postoperatively.

Details
Condition Periapical Lesion
Age 16years - 55years
Treatment Periapical surgery with guided tissue regeneration, Periapical surgery without anyguided tissue regeneration
Clinical Study IdentifierNCT04391725
SponsorPostgraduate Institute of Dental Sciences Rohtak
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients of age 16-55 years with a clinical & radiographic diagnosis of through and through periradicular lesion using CBCT
Negative response to sensitivity tests with radiographic evidence of periapical radiolucency
Failed previous root canal treatment primary or secondary with purulent discharge and radiographic evidence of periapical pathology
The teeth must have adequate final restoration with no clinical evidence of coronal leakage

Exclusion Criteria

Unrestorable tooth
Fractured / perforated tooth
Systemic diseases contraindicating surgical procedures or with potential to affect healing
Teeth with deep pockets
Patient requiring antibiotic premedication
Patients with history of antibiotic use in last 3 months
Smokers
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