Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis

  • STATUS
    Recruiting
  • participants needed
    36
  • sponsor
    Foundation University Islamabad
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Updated on 16 February 2024
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osteoarthritis
conservative management
joint mobilization
knee pain

Summary

Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.

Details
Condition Osteoarthritis of knee, Osteoarthritis, Osteoarthritis
Age 40years - 70years
Treatment Lower Extremity Resistance Exercise Training, Home Exercise Plan, Electrotherapy + Heating, Joint Mobilization, Creatine Supplementation, Glucoseamine/ Chondritin Sulfate Supplementation
Clinical Study IdentifierNCT04423432
SponsorFoundation University Islamabad
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 40-70 years
Knee OA with history not less than three months
Radiological evidences of grade III or less on Kellgren classification
Knee pain on VNRS no more than 8/10

Exclusion Criteria

Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection)
History of trauma or fractures in lower extremity
Signs of lumbar radiculopathy or myelopathy
History of knee surgery or replacement
Patients on intra-articular steroid therapy within two months before the commencement of the study
Impaired skin sensation
Impaired renal function
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