Role of aGVHD Biomarkers on aGVHD Risks

  • STATUS
    Recruiting
  • participants needed
    500
  • sponsor
    Chinese PLA General Hospital
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Updated on 16 February 2024
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hematologic malignancies
allogeneic hematopoietic stem cell transplantation

Summary

To establish risk rating criteria of biological protein marker, determine the role and consistency of aGVHD biomarkers in aGVHD diagnosis and aGVHD prognosis, and evaluate the the impact on non-relapse mortality and relapse and disease free survival, the multicenter study on aGVHD biomarkers detection in the patients underwent allogeneic hematopoietic stem cell transplantation was performed.

Description

  1. To establish standard risk rating criteria of aGVHD biomarkers;
  2. To verify the role of aGVHD biomarkers monitored in predicting aGVHD risks;
  3. To determine the correlation between aGVHD biomarkers monitored and aGVHD risk;
  4. To carry out a observative study in patients with aGVHD treatment about therapeutic protocols and medication efficacy;
  5. To predict the correlation between the high-risk patients with aGVHD and non-relapse mortality and disease free survival;

Details
Condition Biological Markers, GVHD,Acute
Age 65years or below
Treatment aGVHD biomarker
Clinical Study IdentifierNCT04284904
SponsorChinese PLA General Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Diagnosed with hematological diseases
Have underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) from any donor source using bone marrow, peripheral blood stem cells, or cord blood for hematologic malignancies

Exclusion Criteria

recipients of second allogeneic stem cell transplant
pregnant or breast-feeding women
Serum creatinine > 2.0 mg/dL or creatinine clearance < 40 mL/min measured or calculated by Cockroft-Gault equation
human immunodeficiency virus infection
active hepatitis b virus, hepatitis C virus infection and need antivirus treatment
Subjects with evidence of relapsed primary disease, or subjects who have been treated for relapse after the allo-HSCT was performed, or graft rejection
allergic history to Janus kinase inhibitors
Severe organ dysfunction unrelated
Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the subject; or interfere with interpretation of study data
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