ChAracterisation of ItaliaN Severe Uncontrolled Asthmatic patieNts Key Features When Receiving Benralizumab

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    AstraZeneca
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Updated on 16 February 2024
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corticosteroids
asthma
benralizumab

Summary

This is an observational, Italian multi-center, retrospective cohort study with enrollment visit on patients suffering from severe eosinophilic asthma who started benralizumab in the Sampling Program or as per normal clinical practice in Italy.

Description

A retrospective cohort study design involving secondary data collection was chosen to appropriately address the primary objective in a relatively short period of time after enrollment phase initiation: in fact, since the Italian Sampling Program on benralizumab was active since July 2018, clinical data on patients exposed to benralizumab are already available. No treatments will be administered per protocol requirement, but instead according to normal clinical practice; since benralizumab first administration occurs before inclusion in the study (as per chosen study design), the decision to include the patient in the study is clearly separated from the prescription of benralizumab, in accordance with the observational nature of the study. In order to be eligible for the study, for each patient, the index date shall be at least 3 months prior to enrollment.

Details
Condition Severe Asthma
Age 100years or below
Treatment No intervention
Clinical Study IdentifierNCT04272463
SponsorAstraZeneca
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Adult patients (age 18 years) at the start of benralizumab treatment within the sampling program or per clinical practice ("index date")
Patients with severe eosinophilic asthma requiring a stable treatment of high doses of inhaled corticosteroids and a long acting 2 agonist additional asthma controller (according to clinician's judgment)
Patients who started benralizumab and received at least one injection at least 3 months before enrollment, either within the sampling program or as per routine clinical practice
Patients who signed the informed consent and privacy form at enrollment visit
Patients with available hospital medical chart since the start of benralizumab treatment within the sampling program or per clinical practice ("index date")

Exclusion Criteria

Patients who, during the observation period, received benralizumab in a clinical experimental trial
Patients who, during the observation period, participated in studies imposing a specific patient's management strategy which does not correspond to the site's normal clinical practice
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