Fertility After Prostate Brachytherapy

  • STATUS
    Recruiting
  • participants needed
    40
  • sponsor
    East and North Hertfordshire NHS Trust
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Updated on 16 February 2024
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brachytherapy
impotence

Summary

Although brachytherapy toxicity data on erectile dysfunction, urethral dysfunction and bladder and bowel impact has been collected for a number of years, there is limited information on its effect on male fertility. This study aims to investigate the effect of brachytherapy on fertility

Description

Brachytherapy is a commonly employed technique in the treatment of all prostate cancer risk groups. It delivers a high radiation localised to the prostate gland. The effects of this on fertility have not been systematically studied. An increasing number of younger men for whom fertility is an issue are being diagnosed with prostate cancer and may be offered brachytherapy amongst their treatment choices. This study therefore addresses this issue with a systematic evaluation of sperm count and quality before and after both high dose rate and low dose rate brachytherapy.

Details
Condition Malignant neoplasm of prostate, Prostatic disorder
Age 18years - 100years
Clinical Study IdentifierNCT04278443
SponsorEast and North Hertfordshire NHS Trust
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Male
years or older
Receiving brachytherapy monotherapy; High or Low dose rate
Ability to ejaculate
Able to provide written informed consent

Exclusion Criteria

History of infertility or vasectomy
Previous chemotherapy or pelvic radiotherapy
Prior use of androgen deprivation therapy
alpha-reductase inhibitors within the last 4 months
Alpha blockers within 7 days of semen collection
Clear my responses
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