Mechanism of Action of Transcranial Magnetic Stimulation

  • STATUS
    Recruiting
  • participants needed
    54
  • sponsor
    Massachusetts General Hospital
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Updated on 16 February 2024
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depressive disorder
depressive episode
transcranial magnetic stimulation
depression
major depressive disorder
psychiatric treatment
psychiatric therapy
psychiatric care

Summary

This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.

Description

This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar depression receiving TMS. Patients will be scanned before and after a full course of TMS and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of TMS at the circuit level (2) to study the use of fcMRI as a state biomarker for depression (3) to study the use of fcMRI as a predictor of response for depression.

Details
Condition Major depression, Endogenous depression, Depression, Depression
Age 18years - 80years
Treatment Transcranial magnetic stimulation
Clinical Study IdentifierNCT04278521
SponsorMassachusetts General Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Males and females between the ages of 18-80
DSM-IV diagnosis of Depressive Episode
Patients requiring TMS treatment as part of their psychiatric care

Exclusion Criteria

Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia
Substance use disorder (abuse or dependence) with active use within the last 3 months
Severe or unstable medical illness
MRI contraindications as determined by MGH department of radiology
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depressive disorder
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major depressive disorder
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psychiatric therapy
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