Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)

  • STATUS
    Recruiting
  • participants needed
    50
  • sponsor
    Aristotle University Of Thessaloniki
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Updated on 16 February 2024
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glycosylated hemoglobin
hba1c
early diagnosis
hemoglobin a1c
neuropathy
type 1 diabetes mellitus
nerve conduction
diabetic peripheral neuropathy
diabetic neuropathy
early detection
nerve conduction study
mononeuritis
electrophysiological study
diabetes
insulin

Summary

The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy.

Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM.

In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.

Details
Condition Insulin dependent diabetes mellitus, Proteomics, Diabetic Peripheral Neuropathy
Age 5years - 10years
Treatment blood sampling
Clinical Study IdentifierNCT04257877
SponsorAristotle University Of Thessaloniki
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Children with confirmed DT1 under insulin substitution therapy
Age 5-10 years
Good glycemic control with HbA1c 7.0%
Prepubertal patients
Absence of other diseases
Signed informed consent of the parents or guardians of patients

Exclusion Criteria

Presence of organic cause for neuropathy
Presence of other chronic disease
Poor glycemic control
Medication
Clear my responses
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glycosylated hemoglobin
hba1c
early diagnosis
hemoglobin a1c
neuropathy
type 1 diabetes mellitus
nerve conduction
diabetic peripheral neuropathy
diabetic neuropathy
early detection
nerve conduction study
mononeuritis
electrophysiological study
diabetes
insulin

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