Study to Assess AFM24 in Advanced Solid Cancers

  • STATUS
    Recruiting
  • participants needed
    70
  • sponsor
    Affimed GmbH
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Updated on 16 February 2024
See if I qualify
cancer
measurable disease
solid tumour
lung cancer
cancer treatment
kidney cancer
metastatic colorectal cancer
glioblastoma multiforme
colorectal cancer
non-small cell lung cancer
EGFR
small cell lung cancer

Summary

AFM24-101 is a first in human Phase 1/2a open-label, non-randomized, multi-center, multiple ascending dose escalation/expansion study evaluating AFM24 as monotherapy in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.

There will be two parts to this study: a dose escalation phase (1) and a dose expansion phase (2a).

The aim of the dose escalation phase is to determine the maximum tolerated dose (MTD) and establish the recommended Phase 2a dose (RP2D).

The dose escalation phase will be followed by the dose expansion phase once the MTD/RP2D of AFM24 monotherapy has been determined. The dose expansion phase of the study using the MTD/P2D is intended to collect preliminary evidence of efficacy and to further confirm the safety of AFM24 as a monotherapy. The expansion phase will have 4 arms based on tumor type of metastatic colorectal cancer and non-small cell lung cancer.

AFM24 is a tetravalent bispecific (anti-human EGFR x anti-human CD16A) innate immune cell engaging recombinant antibody construct being developed to target EGFR-expressing solid tumors . and has been designed to specifically utilize the cytotoxic potential of the innate immune system, in particular natural killer cells and macrophages for the specific and efficient elimination of EGFR-positive cancer cells.

Details
Condition Advanced Solid Tumor
Age 18years - 100years
Treatment AFM24
Clinical Study IdentifierNCT04259450
SponsorAffimed GmbH
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Histologically or cytologically confirmed advanced or metastatic solid malignancies that are known to express EGFR, or in which EGFR is thought to be a relevant therapeutic target, including but not limiting to: colorectal, lung, gastric, esophageal, pancreatic, head and neck, breast, ovarian, cervical, urothelial, and renal cancers, and Glioblastoma multiforme
Previously treated with one or more lines of anticancer therapy and have documented disease progression during or after their most recent line of anticancer therapy. In addition, either there is no further SOC therapy for the patient or the remaining SOC therapies are deemed not appropriate for the patient by the Investigator
Adequate organ function
Patients must have at least one tumor site that is accessible to biopsy
Phase 2a only: Measurable disease per RECIST v1.1

Exclusion Criteria

Treatment with systemic anticancer therapy within 4 weeks (6 weeks if therapy was mitomycin C and/or nitrosoureas), or within 5 half-lives of the agent if half-life is known and it is shorter, before first dose of study drug. Anticancer therapies include cytotoxic chemotherapy, targeted inhibitors, and immunotherapies, but do not include hormonal therapy or radiotherapy
Radiation therapy within 2 weeks before 1st dose of study drug or unresolved toxicity from previous radiotherapy
History of any other malignancy known to be active, with the exception of completely removed in situ cervical intra-epithelial neoplasia, non-melanoma skin cancer, DCIS, early stage prostate cancer that has been adequately treated, and other cancers from which the patient has been disease free for 3 years or longer
currently participating in a study and receiving study therapy, or participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study treatment
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