Gut Microbiome in Biliary Atresia

  • STATUS
    Recruiting
  • participants needed
    36
  • sponsor
    Yonsei University
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Updated on 16 February 2024
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fibrosis
vaccination
biliary atresia
cholestasis
portoenterostomy
neonatal hepatitis

Summary

The investigator will investigate the gut-microbiome and liver elasticity of the Biliary Atresia (BA)-patients before and after Kasai operation. The data will be analyzed according to their clinical outcomes including cholangitis to find out diagnostic makers, significantly associated with the BA-phenotypes. The decision-making tree for the BA will be updated with our data, which will strength the prognosis and prediction. The establishment of gut-liver axis, featured by cholangitis and gut-microbiome will open new pathway to treat the BA using fecal microbiota transplantation.

  1. Analysis of gut-microbiome: The investigator will investigate the alteration of gut-microbiome by restoration of bile flow at diagnosis, before and after Kasai procedure. In case of cholangitis after Kasai operation, signature gut-microbiome will be analyzed, which will lead to prevention of BA-patients from cholangitis via the bacteria transplantation.
  2. Analysis of elastography: In order to improve non-invasive diagnosis, The investigator will investigate the alteration of liver elasticity and hepatic blood flow before and after Kasai procedure as well as upon cholangitis and choledochal cyst. Those data will be analyzed in parallel with serum biochemical markers to be associated with pathophysiological events e.g., cholestasis, cholangitis and fibrosis.

Details
Condition Biliary Atresia
Age 7years or below
Treatment Monitoring of the gut-microbiome and ultrasound elasticity., Monitoring of the gut-microbiome, Monitoring of the gut-microbiome.
Clinical Study IdentifierNCT04260503
SponsorYonsei University
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

-4 months old
Healthy neonates without chronic diseases when they visit for vaccination
Healthy neonates whose parents or guardian understand our research aims, and comply to participate in our researches

Exclusion Criteria

Patients with hepatobiliary infection
Patients, required to use antibiotics to treat the infection
Neonates with less than 37 weeks (i.e., preterm) or hospitalized in neonatal intensive care unit
Patients, diagnosed with congenital malformation, syndrome and chronic diseases
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